Regulation of lipolysis in severely burned children

R. R. Wolfe, David Herndon, E. J. Peters, F. Jahoor, M. H. Desai, O. B. Holland

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

In this study, the rates of lipid mobilization and of lipolysis have been quantified in severely burned children. In all 12 patients studied, the basal rates were determined. In seven patients, the lipolytic responsiveness to an infusion of epinephrine (0.015 μg/kg/min) was tested, and in the other five patients, the response to beta-adrenergic blockade (propranolol, 1 mg/kg) was tested. The rate of appearance (Ra) of free fatty acids (FFA) was quantified by means of the infusion of 1-13C-palmitate to determine the rate of lipid mobilization, and Ra glycerol was determined using d5-glycerol to assess the rate of lipolysis more directly. In five patients, body composition was determined after recovery by means of H2 18O dilution. The basal rate of lipolysis was higher than normal in the burned children. In four of the seven patients infused with epinephrine, there was a pronounced increase in Ra glycerol. In all patients given beta-blockade, Ra glycerol decreased greatly. Changes in Ra FFA corresponded with the changes in Ra glycerol in each case. Total body fat was very low (approximately 2% body weight), reflecting the surgical removal of fat in the process of burn wound excision. From these data it is concluded that lipolytic responsiveness to catecholamines in severely burned children is variable, but not absent, despite chronically elevated levels of catecholamines. The total extent of lipolysis may be limited by the available fat mass in children treated with fascial excision. In such patients, the limitation in the ability to mobilize an adequate amount of FFA to fully meet energy requirements provides an important rationale for the clinical practice of providing nutritional support in hourly boluses, as opposed to infrequent meals, since any period of even a few hours in which nutrients are not being absorbed will result in an energy substrate deficiency and consequent increase in amino acid oxidation.

Original languageEnglish (US)
Pages (from-to)214-221
Number of pages8
JournalAnnals of Surgery
Volume206
Issue number2
StatePublished - 1987

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Lipolysis
Glycerol
Lipid Mobilization
Nonesterified Fatty Acids
Epinephrine
Catecholamines
Fats
Nutritional Support
Palmitates
Body Composition
Propranolol
Adrenergic Agents
Meals
Adipose Tissue
Body Weight
Amino Acids
Food
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

Cite this

Wolfe, R. R., Herndon, D., Peters, E. J., Jahoor, F., Desai, M. H., & Holland, O. B. (1987). Regulation of lipolysis in severely burned children. Annals of Surgery, 206(2), 214-221.

Regulation of lipolysis in severely burned children. / Wolfe, R. R.; Herndon, David; Peters, E. J.; Jahoor, F.; Desai, M. H.; Holland, O. B.

In: Annals of Surgery, Vol. 206, No. 2, 1987, p. 214-221.

Research output: Contribution to journalArticle

Wolfe, RR, Herndon, D, Peters, EJ, Jahoor, F, Desai, MH & Holland, OB 1987, 'Regulation of lipolysis in severely burned children', Annals of Surgery, vol. 206, no. 2, pp. 214-221.
Wolfe RR, Herndon D, Peters EJ, Jahoor F, Desai MH, Holland OB. Regulation of lipolysis in severely burned children. Annals of Surgery. 1987;206(2):214-221.
Wolfe, R. R. ; Herndon, David ; Peters, E. J. ; Jahoor, F. ; Desai, M. H. ; Holland, O. B. / Regulation of lipolysis in severely burned children. In: Annals of Surgery. 1987 ; Vol. 206, No. 2. pp. 214-221.
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