Regulation of macrophage inflammatory protein-1α expression and function by endogenous interleukin-10 in a model of acute inflammation

Maureen N. Ajuebor, Anuk M. Das, László Virág, Csaba Szabó, Mauro Perretti

    Research output: Contribution to journalArticle

    47 Scopus citations

    Abstract

    In this study we have determined the role of endogenous interleukin (IL)-10 on leucocyte recruitment and production of the CC chemokine macrophage inflammatory protein-1α (MIP-1α) in a murine model of acute inflammation. Intraperitoneal injection of zymosan produced a dose-dependent cellular infiltration which was concomitant with MIP-1α release in the lavage fluids. Release of this chemokine had a functional role since treatment of mice with a specific anti-MIP-1α antibody reduced both neutrophil and monocyte accumulation into the peritoneal cavity. An unexpected increase in cell influx and MIP-1α production was measured following depletion of resident peritoneal macrophages, as achieved by a 3-day liposome treatment. A similar result was obtained when the zymosan peritonitis response was elicited in IL-10 knock-out mice. In summary we propose a functional cross talk between endogenous IL-10 and this CC chemokine during the host inflammatory response.

    Original languageEnglish (US)
    Pages (from-to)279-282
    Number of pages4
    JournalBiochemical and Biophysical Research Communications
    Volume255
    Issue number2
    DOIs
    StatePublished - Feb 16 1999

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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