Regulation of monocyte/macrophage function by adenosine receptors

György Haskó, Csaba Szabo

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Adenosine is an endogenous purine nucleoside that, subsequent to its release from cells or after being generated extracellularly, diffuses to the membrane of surrounding cells, in which it binds to specific cell surface structures that recognize it, termed adenosine receptors. There are four types of adenosine receptors, all of which are members of the G-protein-coupled family of receptors. They are the A1, A2A, A2B, and A3 adenosine receptors. 1-4 Although adenosine is present at low concentrations in the extracellular space, metabolically stressful conditions increase its extracellular levels dramatically. Adenosine receptors are expressed abundantly on cells of the monocyte/macrophage lineage, and through these receptors adenosine exerts substantial modulatory effects on monocyte/macrophage function. 5-7 Because macrophages are activated by stressful stimuli such as inflammation, hypoxia, and ischemia, the same stimuli that can result in accumulation of extracellular adenosine, adenosine receptors expressed on macrophages represent a sensor system providing macrophages with essential information about the inflammatory or ischemic environment. 6 This mechanism allows macrophages to fine-tune their responses to stressful stimuli. In this chapter, we focus on the consequences of adenosine receptor engagement on monocyte and macrophage function. We will delineate the effect of stimulating the various adenosine receptor subtypes on macrophage differentiation/proliferation, phagocytosis, membrane protein expression, and mediator production. A more complete understanding of the regulation of monocyte/macrophage function by adenosine receptor engagement should help develop novel therapeutic ways of manipulating disorders that are associated with exuberant or insufficient macrophage activation.

Original languageEnglish (US)
Title of host publicationAdenosine Receptors
Subtitle of host publicationTherapeutic Aspects for Inflammatory and Immune Diseases
PublisherCRC Press
Pages49-68
Number of pages20
ISBN (Electronic)9781420005776
ISBN (Print)0849339995, 9780849339998
StatePublished - Jan 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Haskó, G., & Szabo, C. (2006). Regulation of monocyte/macrophage function by adenosine receptors. In Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases (pp. 49-68). CRC Press.