Regulation of peptide YY homeostasis by gastric acid and gastrin

Guillermo Gomez, Luis Padilla, Vidyavathi Udupi, Nadya Tarasova, Frank Sundler, Courtney M. Townsend, James C. Thompson, George H Greeley

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Peptide YY (PYY) is a gut hormone localized primarily in the distal bowel. Because circulating PYY inhibits gastric acid secretion, we investigated the effects of gastric acid secretion and gastrin on gene expression and secretion of PYY. In conscious dogs, PYY release in response to oral food was inhibited (P < 0.05) by pharmacologic inhibition of gastric acid secretion (omeprazole, famotidine). In rats, omeprazole treatment resulted in a significant elevation in serum gastrin concentrations and a simultaneous decrease in PYY messenger RNA (mRNA) and peptide levels in the colon; administration of a gastrin receptor antagonist (L365, 260) prevented the inhibitory actions of omeprazole on colonic PYY mRNA levels. In athymic-nude mice, implantation of a human gastrinoma resulted in an elevation of serum gastrin concentrations and a concomitant depression of colonic PYY mRNA levels. We conclude that endogenous gastric acid secretion up-regulates PYY release and PYY mRNA expression. Circulating gastrin acts to down-regulate PYY release and PYY mRNA expression. This study provides evidence that foregut functions (i.e., gastric acid secretion and gastrin release) exert control over an antiacid signal (e.g. PYY release) emanating from the hindgut.

Original languageEnglish (US)
Pages (from-to)1365-1369
Number of pages5
JournalEndocrinology
Volume137
Issue number4
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Endocrinology

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    Gomez, G., Padilla, L., Udupi, V., Tarasova, N., Sundler, F., Townsend, C. M., Thompson, J. C., & Greeley, G. H. (1996). Regulation of peptide YY homeostasis by gastric acid and gastrin. Endocrinology, 137(4), 1365-1369. https://doi.org/10.1210/endo.137.4.8625912