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Regulation of protein-ligand binding affinity by hydrogen bond pairing
Deliang Chen
, Numan Oezguen
, Petri Urvil
, Colin Ferguson
,
Sara M. Dann
, Tor C. Savidge
Internal Medicine
Research output
:
Contribution to journal
›
Article
›
peer-review
765
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Scopus citations
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Dive into the research topics of 'Regulation of protein-ligand binding affinity by hydrogen bond pairing'. Together they form a unique fingerprint.
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Biochemistry, Genetics and Molecular Biology
Binding Affinity
100%
Cell Function
20%
Hydrogen Bond
100%
Ligand Binding
100%
Molecular Interaction
60%
Peptoclostridium difficile
20%
Protein Ligand
100%
Keyphrases
Binding Affinity
7%
Biological Systems
7%
Bonding Process
14%
Bulk Water
14%
Catalytic Power
14%
Cell Behavior
7%
Clostridium Difficile Toxin
7%
Compound Design
7%
Donor-acceptor
7%
Drug Design
7%
Experimental Correlation
7%
High-affinity Binding
7%
Hydrogen Atom
7%
Hydrogen Bonds (H-bonds)
100%
Ligand Binding Affinity
14%
Ligand-receptor Binding
7%
Mechanistic Insight
7%
Melamine
7%
Molecular Function
7%
Molecular Interactions
21%
Natural Design
7%
Oxygen Atom
7%
Pairing Mechanism
7%
Pairing Principles
7%
Protein-ligand Binding Affinity
100%
Receptor-ligand Interaction
7%
Theoretical Correlation
7%
Traditional Drugs
7%
Unresolved Issues
7%
Chemistry
Donor
40%
Hydrogen Bonding
100%
Kd
100%
Lead Compound
40%
Ligand Binding
100%
Melamine
20%
Oxygen Atom
20%
Pharmacology, Toxicology and Pharmaceutical Science
Compounds of Lead
9%
Drug Development
9%
Hydrogen Bond
100%
Lead Compound
9%
Melamine
9%
Peptoclostridium difficile
9%
Protein Ligand
100%
Receptor
18%