Regulation of the immune response by prostaglandins

James S. Goodwin, David R. Webb

Research output: Contribution to journalReview articlepeer-review

561 Scopus citations

Abstract

This paper reviews work on the regulation of humoral and cellular immunity by prostaglandins. A substantial body of evidence implicates prostaglandins E1 and E2 as local feedback inhibitors of T-cell activation in vitro and in vivo. Blockade of prostaglandin synthesis in vitro or in vivo results in an enhanced cellular immune response in a number of different experimental systems. Prostaglandins of the E and F series also modulate humoral immune responses such as B-cell activation or antibody production. Several disease states are discussed where disordered regulation by prostaglandins might have a role in the altered immune responses.

Original languageEnglish (US)
Pages (from-to)106-122
Number of pages17
JournalClinical Immunology and Immunopathology
Volume15
Issue number1
DOIs
StatePublished - Jan 1980
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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