Regulation of the immune response by prostaglandins

James Goodwin, David R. Webb

Research output: Contribution to journalArticle

560 Citations (Scopus)

Abstract

This paper reviews work on the regulation of humoral and cellular immunity by prostaglandins. A substantial body of evidence implicates prostaglandins E1 and E2 as local feedback inhibitors of T-cell activation in vitro and in vivo. Blockade of prostaglandin synthesis in vitro or in vivo results in an enhanced cellular immune response in a number of different experimental systems. Prostaglandins of the E and F series also modulate humoral immune responses such as B-cell activation or antibody production. Several disease states are discussed where disordered regulation by prostaglandins might have a role in the altered immune responses.

Original languageEnglish (US)
Pages (from-to)106-122
Number of pages17
JournalClinical Immunology and Immunopathology
Volume15
Issue number1
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Prostaglandins
Humoral Immunity
Cellular Immunity
Alprostadil
Prostaglandins F
Prostaglandins E
Dinoprostone
Antibody Formation
B-Lymphocytes
T-Lymphocytes
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Regulation of the immune response by prostaglandins. / Goodwin, James; Webb, David R.

In: Clinical Immunology and Immunopathology, Vol. 15, No. 1, 1980, p. 106-122.

Research output: Contribution to journalArticle

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