Regulation of the low affinity receptor for nerve growth factor, p75NGFR, in the olfactory system of neonatal and adult rat

Christopher P. Turner, J. Regino Perez-Polo

    Research output: Contribution to journalArticle

    21 Scopus citations

    Abstract

    Using MAb192, a monoclonal antibody to the rat low affinity receptor for nerve growth factor (p75NGFR), we determined the expression of p75NGFR in rat neonatal and adult olfactory system. In neonates and adults, we observed discrete p75NGFR-immunoreactivity (p75NGFR-ir) in the glomerular layer of the main olfactory bulb. The intensity and organization of glomerular p75NGFR-ir increased with age. This was in keeping with the general ontogeny of the main olfactory bulb. Generally, granule cells, mitral cells and periglomerular cells of the main olfactory bulb were not specifically stained. However, in early neonates, granule cells close to the lateral olfactory tract exhibited p75NGFR-ir. Additional specific staining was found in the olfactory receptor neurons of neonatal and adult olfactory neuroepithelium, the olfactory fascicles and in the glomeruli of the accessory olfactory bulb. The intensity, but not the organization, of specific staining in the accessory olfactory bulb increased as the animal matured. We believe that p75NGFR-ir in the olfactory system is associated with its unique capacity to regenerate its peripheral input to the main olfactory bulb. The presence of p75NGFR-ir in the accessory olfactory bulb would suggest a broader role for this protein. Here we discuss the implications of these findings with regards to nerve growth factor, other trophic molecules, and their receptors. The data presented provide a foundation for studies involving manipulation of regenerative phenomena while monitoring the expression of neurotrophic factors and their receptors.

    Original languageEnglish (US)
    Pages (from-to)343-359
    Number of pages17
    JournalInternational Journal of Developmental Neuroscience
    Volume10
    Issue number5
    DOIs
    StatePublished - Oct 1992

    Keywords

    • central nervous system
    • development
    • nerve growth factor receptor
    • neuroepithelium
    • olfactory
    • rat
    • regeneration

    ASJC Scopus subject areas

    • Developmental Neuroscience
    • Developmental Biology

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