Regulation of the mucosal immune response

P. B. Ernst, F. Song, G. R. Klimpel, H. Haeberle, K. B. Bamford, S. E. Crowe, G. Ye, V. E. Reyes

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Infectious diseases continue to exact an extensive toll on populations living closest to the equatorial regions of the globe. A substantial proportion of these infection s gain access to the host via the mucosal tissues. Thus, the development of new vaccines that enhance mucosal immunity is considered to be of paramount importance in order to prevent or limit the impact of these infections. Mucosal immune responses must discriminate between commensal flora within the lumen and potential pathogens. These responses are highly adapted to induce protection without excessive amounts of inflammation. The balances that regulate mucosal immune and inflammatory responses have to be understood if effective mucosal immunity is to be induced through local immunization. This review will summarize some of the unique properties of mucosal immune responses and focus on recent advances that have significantly influenced our understanding of the regulation of immune and inflammatory responses following infection.

Original languageEnglish (US)
Pages (from-to)2-9
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume60
Issue number4 SUPPL.
DOIs
StatePublished - Apr 1999

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Regulation of the mucosal immune response'. Together they form a unique fingerprint.

Cite this