Regulation of the mucosal immune response

P. B. Ernst, F. Song, G. R. Klimpel, H. Haeberle, K. B. Bamford, S. E. Crowe, G. Ye, Victor Reyes

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Infectious diseases continue to exact an extensive toll on populations living closest to the equatorial regions of the globe. A substantial proportion of these infection s gain access to the host via the mucosal tissues. Thus, the development of new vaccines that enhance mucosal immunity is considered to be of paramount importance in order to prevent or limit the impact of these infections. Mucosal immune responses must discriminate between commensal flora within the lumen and potential pathogens. These responses are highly adapted to induce protection without excessive amounts of inflammation. The balances that regulate mucosal immune and inflammatory responses have to be understood if effective mucosal immunity is to be induced through local immunization. This review will summarize some of the unique properties of mucosal immune responses and focus on recent advances that have significantly influenced our understanding of the regulation of immune and inflammatory responses following infection.

Original languageEnglish (US)
Pages (from-to)2-9
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume60
Issue number4 SUPPL.
StatePublished - Apr 1999

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Mucosal Immunity
Infection
Communicable Diseases
Immunization
Mucous Membrane
Vaccines
Inflammation
Population

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Ernst, P. B., Song, F., Klimpel, G. R., Haeberle, H., Bamford, K. B., Crowe, S. E., ... Reyes, V. (1999). Regulation of the mucosal immune response. American Journal of Tropical Medicine and Hygiene, 60(4 SUPPL.), 2-9.

Regulation of the mucosal immune response. / Ernst, P. B.; Song, F.; Klimpel, G. R.; Haeberle, H.; Bamford, K. B.; Crowe, S. E.; Ye, G.; Reyes, Victor.

In: American Journal of Tropical Medicine and Hygiene, Vol. 60, No. 4 SUPPL., 04.1999, p. 2-9.

Research output: Contribution to journalArticle

Ernst, PB, Song, F, Klimpel, GR, Haeberle, H, Bamford, KB, Crowe, SE, Ye, G & Reyes, V 1999, 'Regulation of the mucosal immune response', American Journal of Tropical Medicine and Hygiene, vol. 60, no. 4 SUPPL., pp. 2-9.
Ernst PB, Song F, Klimpel GR, Haeberle H, Bamford KB, Crowe SE et al. Regulation of the mucosal immune response. American Journal of Tropical Medicine and Hygiene. 1999 Apr;60(4 SUPPL.):2-9.
Ernst, P. B. ; Song, F. ; Klimpel, G. R. ; Haeberle, H. ; Bamford, K. B. ; Crowe, S. E. ; Ye, G. ; Reyes, Victor. / Regulation of the mucosal immune response. In: American Journal of Tropical Medicine and Hygiene. 1999 ; Vol. 60, No. 4 SUPPL. pp. 2-9.
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