Regulation of transcription factors via natural decoys in genomic DNA

Catherine A. Kemme, Dan Nguyen, Abhijnan Chattopadhyay, Junji Iwahara

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Eukaryotic genomic DNA contains numerous high-affinity sites for transcription factors. Only a small fraction of these sites directly regulates target genes. Other high-affinity sites can serve as naturally present decoys that sequester transcription factors. Such natural decoys in genomic DNA may provide novel regulatory mechanisms for transcription factors.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalTranscription
Volume7
Issue number4
DOIs
StatePublished - Aug 7 2016

Keywords

  • decoy
  • regulatory elements
  • sequestration
  • target search
  • transcription factors

ASJC Scopus subject areas

  • Biochemistry
  • Biotechnology
  • Genetics

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