Regulation of water and ion movement in intestine.

D. W. Powell, H. M. Berschneider, L. D. Lawson, H. Martens

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The direction of net fluid transport in the gut is determined by the algebraic sum of Na+ absorption and Cl- secretion. Na+ absorption by small intestinal villous cells and colonic surface cells is controlled primarily by electrically neutral (NaCl) and electrogenic (Na+-glucose, Na+-amino acid, amiloride-insensitive, and amiloride-sensitive Na+ conductance) entry processes in the apical membrane. Neutral NaCl entry appears to be the result of parallel Na+:H- and Cl-:HCO3- exchangers operating at equal stoichiometry. Uncoupled exchangers operating at different stoichiometry may result in net HCO3- absorption (jejunum), net HCO3- secretion (ileum and proximal colon) or HCO3-:Cl- exchange (distal colon). Increases in intracellular cyclic nucleotides and/or ionized Ca2+ inhibit NaCl entry and, in vivo, promote HCO3- and Cl- secretion. Cl- secretion by crypt cells is the result of cyclic nucleotide-mediated or Ca2+-mediated Cl- conductance channels in the apical membrane which allow Cl- to exit down an electrochemical gradient created by a basolateral NaKCl2 entry process. Cyclic nucleotides may act via specific A and G protein kinases. They also release Ca2+ from intracellular stores and thus could alter transport via Ca2+ (and calmodulin)-activated kinases. Ca2+-dependent secretory agents initiate phospholipid hydrolysis and stimulate secretion via the resulting hydrolytic products: arachidonic acid metabolites when bradykinin is the stimulus or diacylglycerol and/or inositol trisphosphate when acetylcholine is the stimulus. The arachidonic acid metabolites may then stimulate cyclic nucleotide production, while diacylglycerol activates a specific Ca2+/phospholipid-dependent protein kinase (C kinase), and inositol trisphosphate releases Ca2+ from the endoplasmic reticulum. The interrelationships between these intracellular messengers and their exact modes of action remain to be clarified.

Original languageEnglish (US)
Pages (from-to)14-33
Number of pages20
JournalCiba Foundation symposium
Volume112
StatePublished - 1985
Externally publishedYes

Fingerprint

Water Movements
Cyclic Nucleotides
Intestines
Ions
Amiloride
Diglycerides
Inositol
Arachidonic Acid
Phospholipids
Colon
Chloride-Bicarbonate Antiporters
Cyclic GMP-Dependent Protein Kinases
Calcium-Calmodulin-Dependent Protein Kinases
Membranes
Intestinal Absorption
Bradykinin
Jejunum
Ileum
Endoplasmic Reticulum
Acetylcholine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Powell, D. W., Berschneider, H. M., Lawson, L. D., & Martens, H. (1985). Regulation of water and ion movement in intestine. Ciba Foundation symposium, 112, 14-33.

Regulation of water and ion movement in intestine. / Powell, D. W.; Berschneider, H. M.; Lawson, L. D.; Martens, H.

In: Ciba Foundation symposium, Vol. 112, 1985, p. 14-33.

Research output: Contribution to journalArticle

Powell, DW, Berschneider, HM, Lawson, LD & Martens, H 1985, 'Regulation of water and ion movement in intestine.', Ciba Foundation symposium, vol. 112, pp. 14-33.
Powell DW, Berschneider HM, Lawson LD, Martens H. Regulation of water and ion movement in intestine. Ciba Foundation symposium. 1985;112:14-33.
Powell, D. W. ; Berschneider, H. M. ; Lawson, L. D. ; Martens, H. / Regulation of water and ion movement in intestine. In: Ciba Foundation symposium. 1985 ; Vol. 112. pp. 14-33.
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