Abstract
Glutathione-S-Transferases (GSTs) have primarily been thought to be xenobiotic metabolizing enzymes that protect cells from toxic drugs and environmental electrophiles. However, in last three decades, these enzymes have emerged as the regulators of oxidative stress-induced signaling and toxicity. 4-Hydroxy-trans 2-nonenal (HNE) an end-product of lipid peroxidation, has been shown to be a major determinant of oxidative stress-induced signaling and toxicity. HNE is involved in signaling pathways, including apoptosis, proliferation, modulation of gene expression, activation of transcription factors/repressors, cell cycle arrest, and differentiation. In this article, available evidence for a major role of GSTs in the regulation of HNE-mediated cell signaling processes through modulation of the intracellular levels of HNE is discussed.
| Original language | English (US) |
|---|---|
| Journal | Free Radical Biology and Medicine |
| DOIs | |
| State | Accepted/In press - Sep 15 2016 |
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Keywords
- 4-hydroxynonenal
- Cell cycle
- Cell signaling
- Glutathione-S-transferases
- Oxidative stress
ASJC Scopus subject areas
- Biochemistry
- Physiology (medical)
Cite this
Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity. / Awasthi, Yogesh C.; Ramana, Kota; Chaudhary, Pankaj; Srivastava, Satish; Awasthi, Sanjay.
In: Free Radical Biology and Medicine, 15.09.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity
AU - Awasthi, Yogesh C.
AU - Ramana, Kota
AU - Chaudhary, Pankaj
AU - Srivastava, Satish
AU - Awasthi, Sanjay
PY - 2016/9/15
Y1 - 2016/9/15
N2 - Glutathione-S-Transferases (GSTs) have primarily been thought to be xenobiotic metabolizing enzymes that protect cells from toxic drugs and environmental electrophiles. However, in last three decades, these enzymes have emerged as the regulators of oxidative stress-induced signaling and toxicity. 4-Hydroxy-trans 2-nonenal (HNE) an end-product of lipid peroxidation, has been shown to be a major determinant of oxidative stress-induced signaling and toxicity. HNE is involved in signaling pathways, including apoptosis, proliferation, modulation of gene expression, activation of transcription factors/repressors, cell cycle arrest, and differentiation. In this article, available evidence for a major role of GSTs in the regulation of HNE-mediated cell signaling processes through modulation of the intracellular levels of HNE is discussed.
AB - Glutathione-S-Transferases (GSTs) have primarily been thought to be xenobiotic metabolizing enzymes that protect cells from toxic drugs and environmental electrophiles. However, in last three decades, these enzymes have emerged as the regulators of oxidative stress-induced signaling and toxicity. 4-Hydroxy-trans 2-nonenal (HNE) an end-product of lipid peroxidation, has been shown to be a major determinant of oxidative stress-induced signaling and toxicity. HNE is involved in signaling pathways, including apoptosis, proliferation, modulation of gene expression, activation of transcription factors/repressors, cell cycle arrest, and differentiation. In this article, available evidence for a major role of GSTs in the regulation of HNE-mediated cell signaling processes through modulation of the intracellular levels of HNE is discussed.
KW - 4-hydroxynonenal
KW - Cell cycle
KW - Cell signaling
KW - Glutathione-S-transferases
KW - Oxidative stress
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UR - http://www.scopus.com/inward/citedby.url?scp=85002590353&partnerID=8YFLogxK
U2 - 10.1016/j.freeradbiomed.2016.10.493
DO - 10.1016/j.freeradbiomed.2016.10.493
M3 - Article
C2 - 27794453
AN - SCOPUS:85002590353
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
SN - 0891-5849
ER -