Regulatory t-cell dynamics in cutaneous and mucocutaneous leishmaniasis due to leishmania braziliensis

Nicolas Barros, Nestor Vasquez, Fernando Woll, Cesar Sanchez, Braulio Valencia, Alejandro Llanos-Cuentas, A. Clinton White, Martin Montes

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

To evaluate the dynamics of regulatory T cells (Tregs) during tegumentary leishmaniasis, we assessed peripheral blood and biopsies from 54 patients. Patients with cutaneous leishmaniasis (CL) had a decreased proportion of Tregs in the peripheral blood, but the proportion was higher in the biopsies of lesions. During treatment of CL, circulating Tregs increased reaching normal proportions, whereas antigen-specific interferon-γ responses diminished. By contrast, circulating Tregs from mucosal leishmaniasis patients failed to normalize during treatment. C-C chemokine receptor type 5 was expressed on a large proportion of Tregs at the site of infection. These results demonstrate increased Tregs at the site of infection, possibly homing from the peripheral circulation.

Original languageEnglish (US)
Pages (from-to)753-758
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume98
Issue number3
DOIs
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

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