Relation between birth weight and weight and height at the age of 2 in children born preterm

Eunice Kennedy Shriver National Institute of Child Health, Human Development Maternal-Fetal Medicine Units Network

Research output: Contribution to journalArticle

Abstract

Objective The aim of the study was to evaluate associations between fetal growth and weight at 2 years in infants born preterm using a customized approach for birth weight. Study Design This is a secondary analysis of a multicenter trial that included a 2-year follow-up of children born prematurely. Customized birth weight percentiles were calculated using the Gardosi model for a U.S. population, and the relation between customized percentile and weight and height at 2 years (adjusted for gender using z-score) was determined using regression analysis and by comparing z-scores for children with birth weight <10th versus ≥10th percentile. Results Weight z-score at 2 years was significantly lower in the <10th than in the ≥10th percentile group (median [interquartile range, IQR]: -0.66 [-1.58, -0.01] vs. -0.23 [-1.05, 0.55]; p < 0.001), and remained after adjusting for maternal education (p < 0.001). A similar relationship was noted for height z-score between groups (median [IQR]: -0.56 [-1.29, 0.19] vs. -0.24 [-0.99, 0.37]; p < 0.001). Positive relationships between customized birth weight percentile and weight and height at 2 years were noted (p < 0.001 for both), but were not strong (R <sup>2</sup>=0.04 and 0.02, respectively). Conclusion Customized birth weight percentile is a minor determinant of weight at 2 years among children born preterm.

Original languageEnglish (US)
Pages (from-to)591-597
Number of pages7
JournalAmerican Journal of Perinatology
Volume32
Issue number6
DOIs
StatePublished - May 1 2015

Fingerprint

Birth Weight
Weights and Measures
Fetal Weight
Fetal Development
Premature Infants
Multicenter Studies
Regression Analysis
Population

Keywords

  • customized birth weight
  • fetal growth potential
  • preterm

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Eunice Kennedy Shriver National Institute of Child Health, & Human Development Maternal-Fetal Medicine Units Network (2015). Relation between birth weight and weight and height at the age of 2 in children born preterm. American Journal of Perinatology, 32(6), 591-597. https://doi.org/10.1055/s-0035-1544947

Relation between birth weight and weight and height at the age of 2 in children born preterm. / Eunice Kennedy Shriver National Institute of Child Health; Human Development Maternal-Fetal Medicine Units Network.

In: American Journal of Perinatology, Vol. 32, No. 6, 01.05.2015, p. 591-597.

Research output: Contribution to journalArticle

Eunice Kennedy Shriver National Institute of Child Health & Human Development Maternal-Fetal Medicine Units Network 2015, 'Relation between birth weight and weight and height at the age of 2 in children born preterm', American Journal of Perinatology, vol. 32, no. 6, pp. 591-597. https://doi.org/10.1055/s-0035-1544947
Eunice Kennedy Shriver National Institute of Child Health, Human Development Maternal-Fetal Medicine Units Network. Relation between birth weight and weight and height at the age of 2 in children born preterm. American Journal of Perinatology. 2015 May 1;32(6):591-597. https://doi.org/10.1055/s-0035-1544947
Eunice Kennedy Shriver National Institute of Child Health ; Human Development Maternal-Fetal Medicine Units Network. / Relation between birth weight and weight and height at the age of 2 in children born preterm. In: American Journal of Perinatology. 2015 ; Vol. 32, No. 6. pp. 591-597.
@article{0919a9fb56c5490d89e233b6548c4e3b,
title = "Relation between birth weight and weight and height at the age of 2 in children born preterm",
abstract = "Objective The aim of the study was to evaluate associations between fetal growth and weight at 2 years in infants born preterm using a customized approach for birth weight. Study Design This is a secondary analysis of a multicenter trial that included a 2-year follow-up of children born prematurely. Customized birth weight percentiles were calculated using the Gardosi model for a U.S. population, and the relation between customized percentile and weight and height at 2 years (adjusted for gender using z-score) was determined using regression analysis and by comparing z-scores for children with birth weight <10th versus ≥10th percentile. Results Weight z-score at 2 years was significantly lower in the <10th than in the ≥10th percentile group (median [interquartile range, IQR]: -0.66 [-1.58, -0.01] vs. -0.23 [-1.05, 0.55]; p < 0.001), and remained after adjusting for maternal education (p < 0.001). A similar relationship was noted for height z-score between groups (median [IQR]: -0.56 [-1.29, 0.19] vs. -0.24 [-0.99, 0.37]; p < 0.001). Positive relationships between customized birth weight percentile and weight and height at 2 years were noted (p < 0.001 for both), but were not strong (R 2=0.04 and 0.02, respectively). Conclusion Customized birth weight percentile is a minor determinant of weight at 2 years among children born preterm.",
keywords = "customized birth weight, fetal growth potential, preterm",
author = "{Eunice Kennedy Shriver National Institute of Child Health} and {Human Development Maternal-Fetal Medicine Units Network} and Gayle Olson and Weiner, {Steven J.} and Rouse, {Dwight J.} and Reddy, {Uma M.} and Mercer, {Brian M.} and Varner, {Michael W.} and Leveno, {Kenneth J.} and Iams, {Jay D.} and Wapner, {Ronald J.} and Ramin, {Susan M.} and Malone, {Fergal D.} and Carpenter, {Marshall W.} and O'Sullivan, {Mary J.} and Dinsmoor, {Mara J.} and Gary Hankins and Caritis, {Steve N.}",
year = "2015",
month = "5",
day = "1",
doi = "10.1055/s-0035-1544947",
language = "English (US)",
volume = "32",
pages = "591--597",
journal = "American Journal of Perinatology",
issn = "0735-1631",
publisher = "Thieme Medical Publishers",
number = "6",

}

TY - JOUR

T1 - Relation between birth weight and weight and height at the age of 2 in children born preterm

AU - Eunice Kennedy Shriver National Institute of Child Health

AU - Human Development Maternal-Fetal Medicine Units Network

AU - Olson, Gayle

AU - Weiner, Steven J.

AU - Rouse, Dwight J.

AU - Reddy, Uma M.

AU - Mercer, Brian M.

AU - Varner, Michael W.

AU - Leveno, Kenneth J.

AU - Iams, Jay D.

AU - Wapner, Ronald J.

AU - Ramin, Susan M.

AU - Malone, Fergal D.

AU - Carpenter, Marshall W.

AU - O'Sullivan, Mary J.

AU - Dinsmoor, Mara J.

AU - Hankins, Gary

AU - Caritis, Steve N.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Objective The aim of the study was to evaluate associations between fetal growth and weight at 2 years in infants born preterm using a customized approach for birth weight. Study Design This is a secondary analysis of a multicenter trial that included a 2-year follow-up of children born prematurely. Customized birth weight percentiles were calculated using the Gardosi model for a U.S. population, and the relation between customized percentile and weight and height at 2 years (adjusted for gender using z-score) was determined using regression analysis and by comparing z-scores for children with birth weight <10th versus ≥10th percentile. Results Weight z-score at 2 years was significantly lower in the <10th than in the ≥10th percentile group (median [interquartile range, IQR]: -0.66 [-1.58, -0.01] vs. -0.23 [-1.05, 0.55]; p < 0.001), and remained after adjusting for maternal education (p < 0.001). A similar relationship was noted for height z-score between groups (median [IQR]: -0.56 [-1.29, 0.19] vs. -0.24 [-0.99, 0.37]; p < 0.001). Positive relationships between customized birth weight percentile and weight and height at 2 years were noted (p < 0.001 for both), but were not strong (R 2=0.04 and 0.02, respectively). Conclusion Customized birth weight percentile is a minor determinant of weight at 2 years among children born preterm.

AB - Objective The aim of the study was to evaluate associations between fetal growth and weight at 2 years in infants born preterm using a customized approach for birth weight. Study Design This is a secondary analysis of a multicenter trial that included a 2-year follow-up of children born prematurely. Customized birth weight percentiles were calculated using the Gardosi model for a U.S. population, and the relation between customized percentile and weight and height at 2 years (adjusted for gender using z-score) was determined using regression analysis and by comparing z-scores for children with birth weight <10th versus ≥10th percentile. Results Weight z-score at 2 years was significantly lower in the <10th than in the ≥10th percentile group (median [interquartile range, IQR]: -0.66 [-1.58, -0.01] vs. -0.23 [-1.05, 0.55]; p < 0.001), and remained after adjusting for maternal education (p < 0.001). A similar relationship was noted for height z-score between groups (median [IQR]: -0.56 [-1.29, 0.19] vs. -0.24 [-0.99, 0.37]; p < 0.001). Positive relationships between customized birth weight percentile and weight and height at 2 years were noted (p < 0.001 for both), but were not strong (R 2=0.04 and 0.02, respectively). Conclusion Customized birth weight percentile is a minor determinant of weight at 2 years among children born preterm.

KW - customized birth weight

KW - fetal growth potential

KW - preterm

UR - http://www.scopus.com/inward/record.url?scp=84940003578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940003578&partnerID=8YFLogxK

U2 - 10.1055/s-0035-1544947

DO - 10.1055/s-0035-1544947

M3 - Article

C2 - 25730133

AN - SCOPUS:84940003578

VL - 32

SP - 591

EP - 597

JO - American Journal of Perinatology

JF - American Journal of Perinatology

SN - 0735-1631

IS - 6

ER -