Relation of Campylobacter pyloridis to gastritis and peptic ulcer

George E. Buck, William K. Gourley, Won K. Lee, Kalyanam Subramanyam, Joan M. Latimer, Anthony R. DiNuzzo

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183 Scopus citations

Abstract

Biopsy specimens from the gastric antral mucosa of 50 patients with upper gastrointestinal complaints were studied by light and electron microscopy and culture. Of 46 assessable specimens, seven were histologically normal, and 39 showed evidence of gastritis. Twenty-seven of the specimens with evidence of gastritis (69%) contained spiral bacteria, whereas only one of the normal specimens (14%) contained these bacteria (P = .02). Of 17 patients found to have gastric ulcers, 10 (59% [P > .10]) also had spiral bacteria. The bacteria could be seen scattered over the surface of the epithelial cells and just under the layer of mucus but were rarely found inside the epithelial cells. Curved or spiral gram-negative bacilli were isolated from 10 of the specimens on chocolate agar incubated at 37 C under microaerophilic conditions. The bacteria resembled the organism recently named Campylobacter pyloridis by other investigators.

Original languageEnglish (US)
Pages (from-to)664-669
Number of pages6
JournalJournal of Infectious Diseases
Volume153
Issue number4
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Buck, G. E., Gourley, W. K., Lee, W. K., Subramanyam, K., Latimer, J. M., & DiNuzzo, A. R. (1986). Relation of Campylobacter pyloridis to gastritis and peptic ulcer. Journal of Infectious Diseases, 153(4), 664-669. https://doi.org/10.1093/infdis/153.4.664