Relationship between 7,12-dimethyl- and 7,8,12-trimethylbenz[a]anthracene DNA adduct formation in hematopoietic organs and leukemogenic effects

Miriam Falzon, Vanessa T. Vu, Peter P. Roller, Snorri S. Thorgeirsson

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The leukemogens 7,12-dimethylbenz[a]anthracene (DMBA) and 7,8,12-trimethylbenz[a]anthracene (TMBA) bind covalently in vivo to DNA of Long-Evans rats in the hematopoietic organs, spleen and bone marrow, and in the liver, a non-target organ. Both TMBA and DMBA depleted bone marrow cells and both agents bound persistently to the DNA of bone marrow and of liver, and less to that of spleen. The three main DMBA: deoxyribonucleoside adducts in spleen, bone marrow and liver were the same as those found previously in the liver (Dipple et al. (1983) Cancer Res., 43, 4132). There were no organ-specific or age-dependent differences in the relative amounts of adducts formed. There appears to be no direct correlation between the susceptibility of an organ to carcinogenesis and the nature and relative amount of the specific adducts formed, at least for the three organs studied here.

Original languageEnglish (US)
Pages (from-to)41-49
Number of pages9
JournalCancer Letters
Volume37
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

9,10-Dimethyl-1,2-benzanthracene
DNA Adducts
Spleen
Bone Marrow
Liver
Deoxyribonucleosides
Long Evans Rats
DNA
Liver Neoplasms
Bone Marrow Cells
Carcinogenesis
7,8,12-trimethylbenz(a)anthracene
diacetylputrescine

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Relationship between 7,12-dimethyl- and 7,8,12-trimethylbenz[a]anthracene DNA adduct formation in hematopoietic organs and leukemogenic effects. / Falzon, Miriam; Vu, Vanessa T.; Roller, Peter P.; Thorgeirsson, Snorri S.

In: Cancer Letters, Vol. 37, No. 1, 1987, p. 41-49.

Research output: Contribution to journalArticle

@article{43110408d38a492cbca93e9d3b27fadb,
title = "Relationship between 7,12-dimethyl- and 7,8,12-trimethylbenz[a]anthracene DNA adduct formation in hematopoietic organs and leukemogenic effects",
abstract = "The leukemogens 7,12-dimethylbenz[a]anthracene (DMBA) and 7,8,12-trimethylbenz[a]anthracene (TMBA) bind covalently in vivo to DNA of Long-Evans rats in the hematopoietic organs, spleen and bone marrow, and in the liver, a non-target organ. Both TMBA and DMBA depleted bone marrow cells and both agents bound persistently to the DNA of bone marrow and of liver, and less to that of spleen. The three main DMBA: deoxyribonucleoside adducts in spleen, bone marrow and liver were the same as those found previously in the liver (Dipple et al. (1983) Cancer Res., 43, 4132). There were no organ-specific or age-dependent differences in the relative amounts of adducts formed. There appears to be no direct correlation between the susceptibility of an organ to carcinogenesis and the nature and relative amount of the specific adducts formed, at least for the three organs studied here.",
author = "Miriam Falzon and Vu, {Vanessa T.} and Roller, {Peter P.} and Thorgeirsson, {Snorri S.}",
year = "1987",
doi = "10.1016/0304-3835(87)90144-3",
language = "English (US)",
volume = "37",
pages = "41--49",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Relationship between 7,12-dimethyl- and 7,8,12-trimethylbenz[a]anthracene DNA adduct formation in hematopoietic organs and leukemogenic effects

AU - Falzon, Miriam

AU - Vu, Vanessa T.

AU - Roller, Peter P.

AU - Thorgeirsson, Snorri S.

PY - 1987

Y1 - 1987

N2 - The leukemogens 7,12-dimethylbenz[a]anthracene (DMBA) and 7,8,12-trimethylbenz[a]anthracene (TMBA) bind covalently in vivo to DNA of Long-Evans rats in the hematopoietic organs, spleen and bone marrow, and in the liver, a non-target organ. Both TMBA and DMBA depleted bone marrow cells and both agents bound persistently to the DNA of bone marrow and of liver, and less to that of spleen. The three main DMBA: deoxyribonucleoside adducts in spleen, bone marrow and liver were the same as those found previously in the liver (Dipple et al. (1983) Cancer Res., 43, 4132). There were no organ-specific or age-dependent differences in the relative amounts of adducts formed. There appears to be no direct correlation between the susceptibility of an organ to carcinogenesis and the nature and relative amount of the specific adducts formed, at least for the three organs studied here.

AB - The leukemogens 7,12-dimethylbenz[a]anthracene (DMBA) and 7,8,12-trimethylbenz[a]anthracene (TMBA) bind covalently in vivo to DNA of Long-Evans rats in the hematopoietic organs, spleen and bone marrow, and in the liver, a non-target organ. Both TMBA and DMBA depleted bone marrow cells and both agents bound persistently to the DNA of bone marrow and of liver, and less to that of spleen. The three main DMBA: deoxyribonucleoside adducts in spleen, bone marrow and liver were the same as those found previously in the liver (Dipple et al. (1983) Cancer Res., 43, 4132). There were no organ-specific or age-dependent differences in the relative amounts of adducts formed. There appears to be no direct correlation between the susceptibility of an organ to carcinogenesis and the nature and relative amount of the specific adducts formed, at least for the three organs studied here.

UR - http://www.scopus.com/inward/record.url?scp=0023280595&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023280595&partnerID=8YFLogxK

U2 - 10.1016/0304-3835(87)90144-3

DO - 10.1016/0304-3835(87)90144-3

M3 - Article

VL - 37

SP - 41

EP - 49

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -