Relationship between glutathione levels and drug or radiation sensitivities in human gastric cancer cell lines in vitro

S. C. Barranco, B. Weintraub, K. K. MacLean, E. G. Beasley, V. K. Jenkins, Courtney Townsend

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Permanent cell lines and clones established from an untreated patient (AGS cells) with gastric carcinoma, and from a similar patient who had been treated with Adriamycin, 5FU and cytoxan (SII cells) were used in a study that compared their drug and radiation survival sensitivities to their glutathidine (GSH) values. The SII parental cell line was more resistant than the AGS cells in vitro to chlorambucil, ACT D, Adria, Bleo, and X-rays. This greater resistance was positively correlated with GSH values that were 1.77 times higher than in the AGS parental cell line. By contrast the SII parental cells were more sensitive than the AGS cells to MeCCNU and Melphalan. The drug and radiation sensitives expressed among the clones of the two cell lines were heterogeneous and did not correlate with their GSH values.

Original languageEnglish (US)
Pages (from-to)29-36
Number of pages8
JournalInvestigational New Drugs
Volume9
Issue number1
DOIs
StatePublished - Feb 1991

Fingerprint

Radiation Tolerance
Stomach Neoplasms
Glutathione
Cell Line
Pharmaceutical Preparations
Semustine
Clone Cells
Chlorambucil
Melphalan
Fluorouracil
Doxorubicin
Cyclophosphamide
Stomach
X-Rays
In Vitro Techniques
Radiation
Carcinoma
Survival

Keywords

  • gastric cancer
  • glutathione
  • heterogeneity
  • resistance

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Relationship between glutathione levels and drug or radiation sensitivities in human gastric cancer cell lines in vitro. / Barranco, S. C.; Weintraub, B.; MacLean, K. K.; Beasley, E. G.; Jenkins, V. K.; Townsend, Courtney.

In: Investigational New Drugs, Vol. 9, No. 1, 02.1991, p. 29-36.

Research output: Contribution to journalArticle

Barranco, S. C. ; Weintraub, B. ; MacLean, K. K. ; Beasley, E. G. ; Jenkins, V. K. ; Townsend, Courtney. / Relationship between glutathione levels and drug or radiation sensitivities in human gastric cancer cell lines in vitro. In: Investigational New Drugs. 1991 ; Vol. 9, No. 1. pp. 29-36.
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