Relationship between phagocytosis and immunoglobulin A release from human colostral macrophages

E. A. Weaver, H. Tsuda, R. M. Goldblum, A. S. Goldman, C. P. Davis

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Macrophages and neutrophils that contain mainly secretory immunoglobulin A (IgA) comprise the majority of cells in human colostrum. These cell populations were separated and analyzed for their ability to release total IgA and secretory IgA when stimulated to phagocytose. Colostral macrophages phagocytosed opsonized bacteria and nonopsonized latex particles; at the same time, IgA was released. Neutrophils poorly phagocytosed opsonized bacteria but actively phagocytosed latex particles. In contrast to the macrophages, the neutrophils did not release IgA, even after active phagocystosis of latex. Consequently, colostral macrophages are the main source of IgA released from colostral leukocytes when these cells are exposed to organisms or particles that are phagocytosed. A function for colostral neutrophils which sequester IgA is proposed.

Original languageEnglish (US)
Pages (from-to)1073-1077
Number of pages5
JournalInfection and Immunity
Volume38
Issue number3
StatePublished - 1982

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Phagocytosis
Immunoglobulin A
Macrophages
Neutrophils
Secretory Immunoglobulin A
Microspheres
Bacteria
Colostrum
Latex
Leukocytes
Population

ASJC Scopus subject areas

  • Immunology

Cite this

Weaver, E. A., Tsuda, H., Goldblum, R. M., Goldman, A. S., & Davis, C. P. (1982). Relationship between phagocytosis and immunoglobulin A release from human colostral macrophages. Infection and Immunity, 38(3), 1073-1077.

Relationship between phagocytosis and immunoglobulin A release from human colostral macrophages. / Weaver, E. A.; Tsuda, H.; Goldblum, R. M.; Goldman, A. S.; Davis, C. P.

In: Infection and Immunity, Vol. 38, No. 3, 1982, p. 1073-1077.

Research output: Contribution to journalArticle

Weaver, EA, Tsuda, H, Goldblum, RM, Goldman, AS & Davis, CP 1982, 'Relationship between phagocytosis and immunoglobulin A release from human colostral macrophages', Infection and Immunity, vol. 38, no. 3, pp. 1073-1077.
Weaver EA, Tsuda H, Goldblum RM, Goldman AS, Davis CP. Relationship between phagocytosis and immunoglobulin A release from human colostral macrophages. Infection and Immunity. 1982;38(3):1073-1077.
Weaver, E. A. ; Tsuda, H. ; Goldblum, R. M. ; Goldman, A. S. ; Davis, C. P. / Relationship between phagocytosis and immunoglobulin A release from human colostral macrophages. In: Infection and Immunity. 1982 ; Vol. 38, No. 3. pp. 1073-1077.
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