Relationship between phagocytosis and immunoglobulin A release from human colostral macrophages

E. A. Weaver, H. Tsuda, R. M. Goldblum, A. S. Goldman, C. P. Davis

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Macrophages and neutrophils that contain mainly secretory immunoglobulin A (IgA) comprise the majority of cells in human colostrum. These cell populations were separated and analyzed for their ability to release total IgA and secretory IgA when stimulated to phagocytose. Colostral macrophages phagocytosed opsonized bacteria and nonopsonized latex particles; at the same time, IgA was released. Neutrophils poorly phagocytosed opsonized bacteria but actively phagocytosed latex particles. In contrast to the macrophages, the neutrophils did not release IgA, even after active phagocystosis of latex. Consequently, colostral macrophages are the main source of IgA released from colostral leukocytes when these cells are exposed to organisms or particles that are phagocytosed. A function for colostral neutrophils which sequester IgA is proposed.

Original languageEnglish (US)
Pages (from-to)1073-1077
Number of pages5
JournalUnknown Journal
Volume38
Issue number3
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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