Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease

Dennis J. Zgaljardic, Joan C. Borod, Nancy S. Foldi, Mary Rocco, Paul J. Mattis, Mark F. Gordon, Andrew S. Feigin, David Eidelberg

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

OBJECTIVE: The prevalence of apathy was assessed across select cognitive and psychiatric variables in 32 nondemented patients with Parkinson disease (PD) and 29 demographically matched healthy control participants. BACKGROUND: Apathy is common in PD, although differentiating apathy from motor, cognitive, and/or other neuropsychiatric symptoms can be challenging. Previous studies have reported a positive relationship between apathy and cognitive impairment, particularly executive dysfunction. METHOD: Patients were categorized according to apathy symptom severity. Stringent criteria were used to exclude patients with dementia. RESULTS: Approximately 44% of patients endorsed significant levels of apathy. Those patients performed worse than patients with nonsignificant levels of apathy on select measures of verbal fluency and on a measure of verbal and nonverbal conceptualization. Further, they reported a greater number of symptoms related to depression and behavioral disturbance than did those patients with nonsignificant levels of apathy. Apathy was significantly related to self-report of depression and executive dysfunction. Performance on cognitive tasks assessing verbal fluency, working memory, and verbal abstraction and also on a self-report measure of executive dysfunction was shown to significantly predict increasing levels of apathy. CONCLUSIONS: Our findings suggest that apathy in nondemented patients with PD seems to be strongly associated with executive dysfunction.

Original languageEnglish (US)
Pages (from-to)184-192
Number of pages9
JournalCognitive and Behavioral Neurology
Volume20
Issue number3
DOIs
StatePublished - Sep 2007

Fingerprint

Apathy
Parkinson Disease
Self Report
Depression
Short-Term Memory
Psychiatry
Dementia
Healthy Volunteers

Keywords

  • Apathy
  • Executive dysfunction
  • Neuropsychologic assessment
  • Parkinson disease

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Behavioral Neuroscience
  • Cognitive Neuroscience

Cite this

Zgaljardic, D. J., Borod, J. C., Foldi, N. S., Rocco, M., Mattis, P. J., Gordon, M. F., ... Eidelberg, D. (2007). Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease. Cognitive and Behavioral Neurology, 20(3), 184-192. https://doi.org/10.1097/WNN.0b013e318145a6f6

Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease. / Zgaljardic, Dennis J.; Borod, Joan C.; Foldi, Nancy S.; Rocco, Mary; Mattis, Paul J.; Gordon, Mark F.; Feigin, Andrew S.; Eidelberg, David.

In: Cognitive and Behavioral Neurology, Vol. 20, No. 3, 09.2007, p. 184-192.

Research output: Contribution to journalArticle

Zgaljardic, DJ, Borod, JC, Foldi, NS, Rocco, M, Mattis, PJ, Gordon, MF, Feigin, AS & Eidelberg, D 2007, 'Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease', Cognitive and Behavioral Neurology, vol. 20, no. 3, pp. 184-192. https://doi.org/10.1097/WNN.0b013e318145a6f6
Zgaljardic, Dennis J. ; Borod, Joan C. ; Foldi, Nancy S. ; Rocco, Mary ; Mattis, Paul J. ; Gordon, Mark F. ; Feigin, Andrew S. ; Eidelberg, David. / Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease. In: Cognitive and Behavioral Neurology. 2007 ; Vol. 20, No. 3. pp. 184-192.
@article{a24dd88268214d6ca7cbdae3ea776f1a,
title = "Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease",
abstract = "OBJECTIVE: The prevalence of apathy was assessed across select cognitive and psychiatric variables in 32 nondemented patients with Parkinson disease (PD) and 29 demographically matched healthy control participants. BACKGROUND: Apathy is common in PD, although differentiating apathy from motor, cognitive, and/or other neuropsychiatric symptoms can be challenging. Previous studies have reported a positive relationship between apathy and cognitive impairment, particularly executive dysfunction. METHOD: Patients were categorized according to apathy symptom severity. Stringent criteria were used to exclude patients with dementia. RESULTS: Approximately 44{\%} of patients endorsed significant levels of apathy. Those patients performed worse than patients with nonsignificant levels of apathy on select measures of verbal fluency and on a measure of verbal and nonverbal conceptualization. Further, they reported a greater number of symptoms related to depression and behavioral disturbance than did those patients with nonsignificant levels of apathy. Apathy was significantly related to self-report of depression and executive dysfunction. Performance on cognitive tasks assessing verbal fluency, working memory, and verbal abstraction and also on a self-report measure of executive dysfunction was shown to significantly predict increasing levels of apathy. CONCLUSIONS: Our findings suggest that apathy in nondemented patients with PD seems to be strongly associated with executive dysfunction.",
keywords = "Apathy, Executive dysfunction, Neuropsychologic assessment, Parkinson disease",
author = "Zgaljardic, {Dennis J.} and Borod, {Joan C.} and Foldi, {Nancy S.} and Mary Rocco and Mattis, {Paul J.} and Gordon, {Mark F.} and Feigin, {Andrew S.} and David Eidelberg",
year = "2007",
month = "9",
doi = "10.1097/WNN.0b013e318145a6f6",
language = "English (US)",
volume = "20",
pages = "184--192",
journal = "Cognitive and Behavioral Neurology",
issn = "1543-3633",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Relationship between self-reported apathy and executive dysfunction in nondemented patients with Parkinson disease

AU - Zgaljardic, Dennis J.

AU - Borod, Joan C.

AU - Foldi, Nancy S.

AU - Rocco, Mary

AU - Mattis, Paul J.

AU - Gordon, Mark F.

AU - Feigin, Andrew S.

AU - Eidelberg, David

PY - 2007/9

Y1 - 2007/9

N2 - OBJECTIVE: The prevalence of apathy was assessed across select cognitive and psychiatric variables in 32 nondemented patients with Parkinson disease (PD) and 29 demographically matched healthy control participants. BACKGROUND: Apathy is common in PD, although differentiating apathy from motor, cognitive, and/or other neuropsychiatric symptoms can be challenging. Previous studies have reported a positive relationship between apathy and cognitive impairment, particularly executive dysfunction. METHOD: Patients were categorized according to apathy symptom severity. Stringent criteria were used to exclude patients with dementia. RESULTS: Approximately 44% of patients endorsed significant levels of apathy. Those patients performed worse than patients with nonsignificant levels of apathy on select measures of verbal fluency and on a measure of verbal and nonverbal conceptualization. Further, they reported a greater number of symptoms related to depression and behavioral disturbance than did those patients with nonsignificant levels of apathy. Apathy was significantly related to self-report of depression and executive dysfunction. Performance on cognitive tasks assessing verbal fluency, working memory, and verbal abstraction and also on a self-report measure of executive dysfunction was shown to significantly predict increasing levels of apathy. CONCLUSIONS: Our findings suggest that apathy in nondemented patients with PD seems to be strongly associated with executive dysfunction.

AB - OBJECTIVE: The prevalence of apathy was assessed across select cognitive and psychiatric variables in 32 nondemented patients with Parkinson disease (PD) and 29 demographically matched healthy control participants. BACKGROUND: Apathy is common in PD, although differentiating apathy from motor, cognitive, and/or other neuropsychiatric symptoms can be challenging. Previous studies have reported a positive relationship between apathy and cognitive impairment, particularly executive dysfunction. METHOD: Patients were categorized according to apathy symptom severity. Stringent criteria were used to exclude patients with dementia. RESULTS: Approximately 44% of patients endorsed significant levels of apathy. Those patients performed worse than patients with nonsignificant levels of apathy on select measures of verbal fluency and on a measure of verbal and nonverbal conceptualization. Further, they reported a greater number of symptoms related to depression and behavioral disturbance than did those patients with nonsignificant levels of apathy. Apathy was significantly related to self-report of depression and executive dysfunction. Performance on cognitive tasks assessing verbal fluency, working memory, and verbal abstraction and also on a self-report measure of executive dysfunction was shown to significantly predict increasing levels of apathy. CONCLUSIONS: Our findings suggest that apathy in nondemented patients with PD seems to be strongly associated with executive dysfunction.

KW - Apathy

KW - Executive dysfunction

KW - Neuropsychologic assessment

KW - Parkinson disease

UR - http://www.scopus.com/inward/record.url?scp=36649027664&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36649027664&partnerID=8YFLogxK

U2 - 10.1097/WNN.0b013e318145a6f6

DO - 10.1097/WNN.0b013e318145a6f6

M3 - Article

C2 - 17846518

AN - SCOPUS:36649027664

VL - 20

SP - 184

EP - 192

JO - Cognitive and Behavioral Neurology

JF - Cognitive and Behavioral Neurology

SN - 1543-3633

IS - 3

ER -