Relationship between Target Cell Cycle and Susceptibility to Natural Killer Lysis

Alan L. Landay, Daniela Zarcone, Carlo E. Grossi, Kenneth Bauer

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Studies from several laboratories have evaluated the role of cell surface antigenic molecules on target cells in natural killer (NK)-mediated cytotoxicity. A number of these cell surface molecules are associated with cell proliferation and may be expressed preferentially during one phase of the cell cycle. The purpose of this investigation was to evaluate the role that target cell cycle plays in susceptibility to NK lysis. Enrichment (>80%) of cells from NK-resistant and NK-sensitive cell lines in the G0G1S, and G2M phases of the cell cycle was achieved by centrifugal elutriation. We demonstrate that there was no influence of cell cycle on NK-mediated lysis of NK-resistant or susceptible cell lines.

Original languageEnglish (US)
Pages (from-to)2767-2770
Number of pages4
JournalCancer Research
Issue number11
StatePublished - Jun 1 1987
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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