Relationship of interleukin-8 and colony-stimulating factors to neutrophil migration in aseptic meningitis

T. Yokoyama, M. Oda, S. Ogura, T. Horiuchi, Y. Seino

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Polymorphonuclear neutrophilic leucocyte (PMNL) migration into the subarachnoid space in aseptic meningitis of probable enteroviral aetiology was evaluated in relation to cerebrospinal fluid and serum levels of interleukin-8 (IL-8), macrophage colony-stimulating factor (M-CSF) and granulocyte colony-stimulating factor (G-CSF). IL-8 levels reached a plateau within 12 h of onset, while M-CSF and G-CSF levels reached a peak between 12 and 24 h after onset, corresponding to the peak increase in PMNL count. G-CSF levels had the closest correlation with PMNL count. M-CSF levels were weakly correlated with PMNL count. IL-8 levels were not correlated with PMNL count except within 12 h of onset. IL-8 and G-CSF were detected predominantly in cerebrospinal fluid, while the M-CSF levels in the two compartments were not different except between 12 and 24 h after onset. It is considered that IL-8 triggers rapid and transient migration of PMNL, and that G-CSF then promotes gradual and consistent infiltration of PMNL.

Original languageEnglish (US)
Pages (from-to)303-307
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Issue number3
StatePublished - 1996
Externally publishedYes


  • Aseptic meningitis
  • Enterovirus
  • Granulocyte colony-stimulating factor
  • Interleukin-8
  • Macrophage colony-stimulating factor
  • Neutrophil

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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