Relationship of Medication Management Test-Revised (MMT-R) performance to neuropsychological functioning and antiretroviral adherence in adults with HIV

Doyle E. Patton, Steven Paul Woods, Donald Franklin, Jordan E. Cattie, Robert K. Heaton, Ann C. Collier, Christina Marra, David Clifford, Benjamin Gelman, Justin McArthur, Susan Morgello, Susan Simpson, J. Allen McCutchan, Igor Grant

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15 Scopus citations

Abstract

While performance-based tests of everyday functioning offer promise in facilitating diagnosis and classification of HIV-associated neurocognitive disorders (HAND), there remains a dearth of well-validated instruments. In the present study, clinical correlates of performance on one such measure (i.e., Medication Management Test - Revised; MMT-R) were examined in 448 HIV+ adults who were prescribed antiretroviral therapy. Significant bivariate relationships were found between MMT-R scores and demographics (e.g., education), hepatitis C coinfection, estimated premorbid IQ, neuropsychological functioning, and practical work abilities. MMT-R scores were not related to HIV disease severity, psychiatric factors, or self-reported adherence among participants with a broad range of current health status. However, lower MMT-R scores were strongly and uniquely associated with poorer adherence among participants with CD4 T cell counts <200. In multivariate analyses, MMT-R scores were predicted by practical work abilities, estimated premorbid functioning, attention/working memory, learning, and education. Findings provide overall mixed support for the construct validity of the MMT-R and are discussed in the context of their clinical and research implications for evaluation of HAND.

Original languageEnglish (US)
Pages (from-to)2286-2296
Number of pages11
JournalAIDS and Behavior
Volume16
Issue number8
DOIs
StatePublished - Nov 2012

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Keywords

  • Adherence
  • Construct validity
  • HIV
  • Instrumental activities of daily living
  • Medication management
  • Neuropsychological functioning

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Social Psychology

Cite this

Patton, D. E., Woods, S. P., Franklin, D., Cattie, J. E., Heaton, R. K., Collier, A. C., Marra, C., Clifford, D., Gelman, B., McArthur, J., Morgello, S., Simpson, S., McCutchan, J. A., & Grant, I. (2012). Relationship of Medication Management Test-Revised (MMT-R) performance to neuropsychological functioning and antiretroviral adherence in adults with HIV. AIDS and Behavior, 16(8), 2286-2296. https://doi.org/10.1007/s10461-012-0237-7