Release of chemical mediators from both allergic and non allergic human leukocytes

J. A. Grant, E. Dupree, A. S. Goldman

Research output: Contribution to journalArticle


The present report suggests that activation of complement is a second mechanism for the release of histamine and SRS A from human basophils. Indeed, basophils, like neutrophils, may have a receptor for activated complement fragments such as C5a. The biological significance of complement induced release of allergic mediators has not been substantially investigated. However, on the basis of studies already done in other species, one might predict a role for complement initiated release of histamine and SRS A in human inflammation.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalInternational Archives of Allergy and Applied Immunology
Issue number1-2
StatePublished - 1975


ASJC Scopus subject areas

  • Immunology and Allergy

Cite this