The present report suggests that activation of complement is a second mechanism for the release of histamine and SRS A from human basophils. Indeed, basophils, like neutrophils, may have a receptor for activated complement fragments such as C5a. The biological significance of complement induced release of allergic mediators has not been substantially investigated. However, on the basis of studies already done in other species, one might predict a role for complement initiated release of histamine and SRS A in human inflammation.
|Original language||English (US)|
|Number of pages||4|
|Journal||International Archives of Allergy and Applied Immunology|
|State||Published - 1975|
ASJC Scopus subject areas
- Immunology and Allergy