Release of chemical mediators from both allergic and non allergic human leukocytes

J. A. Grant, E. Dupree, A. S. Goldman

Research output: Contribution to journalArticle

Abstract

The present report suggests that activation of complement is a second mechanism for the release of histamine and SRS A from human basophils. Indeed, basophils, like neutrophils, may have a receptor for activated complement fragments such as C5a. The biological significance of complement induced release of allergic mediators has not been substantially investigated. However, on the basis of studies already done in other species, one might predict a role for complement initiated release of histamine and SRS A in human inflammation.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
JournalInternational Archives of Allergy and Applied Immunology
Volume49
Issue number1-2
StatePublished - 1975

Fingerprint

SRS-A
Basophils
Histamine Release
Leukocytes
Complement Receptors
Complement Activation
Neutrophils
Inflammation

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Release of chemical mediators from both allergic and non allergic human leukocytes. / Grant, J. A.; Dupree, E.; Goldman, A. S.

In: International Archives of Allergy and Applied Immunology, Vol. 49, No. 1-2, 1975, p. 111-114.

Research output: Contribution to journalArticle

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