Release of cholecystokinin in response to food and intraduodenal fat in pigs, dogs and man

  • P. Lilja
  • , I. Wiener
  • , K. Inoue
  • , G. M. Fried
  • , G. H. Greeley
  • , J. C. Thompson

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was done to compare endogenous cholecystokinin-33 release in response to physiologic stimuli (meal, fat) in pigs, dogs and man. Plasma levels of cholecystokinin-33 were monitored using a radioimmunoassay for cholecystokinin which detects only cholecystokinin-33 and cholecystokinin-39. Ingestion of a meal caused release of cholecystokinin-33 within five, 20 and 120 minutes in man, pigs and dogs, respectively. Intraduodenal administration of corn oil resulted in a significant release of cholecystokinin-33 within 20 minutes in dogs, pigs and man.

Original languageEnglish (US)
Pages (from-to)557-561
Number of pages5
JournalSurgery Gynecology and Obstetrics
Volume159
Issue number6
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

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