Release of neurotensin by selective perfusion of the jejunum with oleic acid in dogs

Masaki Fujimura, Talaat Khalil, Tsuguo Sakamoto, George H. Greeley, Michael G. Salter, Courtney Townsend, James C. Thompson

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Plasma neurotensin concentrations are rapidly elevated after oral ingestion or intraduodenal infusion of fat, apparently before fat reaches the ileum where neurotensin is highly concentrated. The purpose of this study was to investigate the site of neurotensin release and to determine whether neurotensin is released by direct luminal stimulation by fat in conscious dogs. Dogs were prepared with isolated jejunal or ileal segments and portal vein catheters. Release of neurotensin into the portal venous blood was examined by selective perfusion of each intestinal segment with sodium oleate. The results of this study show that selective perfusion of the jejunum, but not the ileum, with sodium oleate, caused a significant release of neurotensin. We speculate that release of ileal neurotensin is not due to direct luminal stimulation, but is mediated by local neural or humoral intermediates.

Original languageEnglish (US)
Pages (from-to)1502-1505
Number of pages4
JournalGastroenterology
Volume96
Issue number6
StatePublished - 1989

Fingerprint

Neurotensin
Jejunum
Oleic Acid
Perfusion
Dogs
Fats
Ileum
Portal Vein
Catheters
Eating

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Fujimura, M., Khalil, T., Sakamoto, T., Greeley, G. H., Salter, M. G., Townsend, C., & Thompson, J. C. (1989). Release of neurotensin by selective perfusion of the jejunum with oleic acid in dogs. Gastroenterology, 96(6), 1502-1505.

Release of neurotensin by selective perfusion of the jejunum with oleic acid in dogs. / Fujimura, Masaki; Khalil, Talaat; Sakamoto, Tsuguo; Greeley, George H.; Salter, Michael G.; Townsend, Courtney; Thompson, James C.

In: Gastroenterology, Vol. 96, No. 6, 1989, p. 1502-1505.

Research output: Contribution to journalArticle

Fujimura, M, Khalil, T, Sakamoto, T, Greeley, GH, Salter, MG, Townsend, C & Thompson, JC 1989, 'Release of neurotensin by selective perfusion of the jejunum with oleic acid in dogs', Gastroenterology, vol. 96, no. 6, pp. 1502-1505.
Fujimura M, Khalil T, Sakamoto T, Greeley GH, Salter MG, Townsend C et al. Release of neurotensin by selective perfusion of the jejunum with oleic acid in dogs. Gastroenterology. 1989;96(6):1502-1505.
Fujimura, Masaki ; Khalil, Talaat ; Sakamoto, Tsuguo ; Greeley, George H. ; Salter, Michael G. ; Townsend, Courtney ; Thompson, James C. / Release of neurotensin by selective perfusion of the jejunum with oleic acid in dogs. In: Gastroenterology. 1989 ; Vol. 96, No. 6. pp. 1502-1505.
@article{77c86662c7e44f2f80c22ed7e10de95f,
title = "Release of neurotensin by selective perfusion of the jejunum with oleic acid in dogs",
abstract = "Plasma neurotensin concentrations are rapidly elevated after oral ingestion or intraduodenal infusion of fat, apparently before fat reaches the ileum where neurotensin is highly concentrated. The purpose of this study was to investigate the site of neurotensin release and to determine whether neurotensin is released by direct luminal stimulation by fat in conscious dogs. Dogs were prepared with isolated jejunal or ileal segments and portal vein catheters. Release of neurotensin into the portal venous blood was examined by selective perfusion of each intestinal segment with sodium oleate. The results of this study show that selective perfusion of the jejunum, but not the ileum, with sodium oleate, caused a significant release of neurotensin. We speculate that release of ileal neurotensin is not due to direct luminal stimulation, but is mediated by local neural or humoral intermediates.",
author = "Masaki Fujimura and Talaat Khalil and Tsuguo Sakamoto and Greeley, {George H.} and Salter, {Michael G.} and Courtney Townsend and Thompson, {James C.}",
year = "1989",
language = "English (US)",
volume = "96",
pages = "1502--1505",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Release of neurotensin by selective perfusion of the jejunum with oleic acid in dogs

AU - Fujimura, Masaki

AU - Khalil, Talaat

AU - Sakamoto, Tsuguo

AU - Greeley, George H.

AU - Salter, Michael G.

AU - Townsend, Courtney

AU - Thompson, James C.

PY - 1989

Y1 - 1989

N2 - Plasma neurotensin concentrations are rapidly elevated after oral ingestion or intraduodenal infusion of fat, apparently before fat reaches the ileum where neurotensin is highly concentrated. The purpose of this study was to investigate the site of neurotensin release and to determine whether neurotensin is released by direct luminal stimulation by fat in conscious dogs. Dogs were prepared with isolated jejunal or ileal segments and portal vein catheters. Release of neurotensin into the portal venous blood was examined by selective perfusion of each intestinal segment with sodium oleate. The results of this study show that selective perfusion of the jejunum, but not the ileum, with sodium oleate, caused a significant release of neurotensin. We speculate that release of ileal neurotensin is not due to direct luminal stimulation, but is mediated by local neural or humoral intermediates.

AB - Plasma neurotensin concentrations are rapidly elevated after oral ingestion or intraduodenal infusion of fat, apparently before fat reaches the ileum where neurotensin is highly concentrated. The purpose of this study was to investigate the site of neurotensin release and to determine whether neurotensin is released by direct luminal stimulation by fat in conscious dogs. Dogs were prepared with isolated jejunal or ileal segments and portal vein catheters. Release of neurotensin into the portal venous blood was examined by selective perfusion of each intestinal segment with sodium oleate. The results of this study show that selective perfusion of the jejunum, but not the ileum, with sodium oleate, caused a significant release of neurotensin. We speculate that release of ileal neurotensin is not due to direct luminal stimulation, but is mediated by local neural or humoral intermediates.

UR - http://www.scopus.com/inward/record.url?scp=0024383680&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024383680&partnerID=8YFLogxK

M3 - Article

VL - 96

SP - 1502

EP - 1505

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 6

ER -