Release of neurotensin by selective perfusion of the jejunum with oleic acid in dogs

Masaki Fujimura, Talaat Khalil, Tsuguo Sakamoto, George H. Greeley, Michael G. Salter, Courtney M. Townsend, James C. Thompson

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Plasma neurotensin concentrations are rapidly elevated after oral ingestion or intraduodenal infusion of fat, apparently before fat reaches the ileum where neurotensin is highly concentrated. The purpose of this study was to investigate the site of neurotensin release and to determine whether neurotensin is released by direct luminal stimulation by fat in conscious dogs. Dogs were prepared with isolated jejunal or ileal segments and portal vein catheters. Release of neurotensin into the portal venous blood was examined by selective perfusion of each intestinal segment with sodium oleate. The results of this study show that selective perfusion of the jejunum, but not the ileum, with sodium oleate, caused a significant release of neurotensin. We speculate that release of ileal neurotensin is not due to direct luminal stimulation, but is mediated by local neural or humoral intermediates.

Original languageEnglish (US)
Pages (from-to)1502-1505
Number of pages4
Issue number6
StatePublished - Jun 1989
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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