Reliable lymphatic drainage to axillary sentinel lymph nodes regardless of tumor location within the breast

Celia Chao, Sandra L. Wong, Claudine Woo, Michael J. Edwards, Todd Turtle, R. Dirk Noyes, David J. Carlson, Peter Turk, Diana Simpson, Kelly M. McMasters

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: This analysis was performed in order to determine whether primary tumor location in breast cancer affects the axillary sentinel lymph node (SLN) identification (ID) rate, the false negative (FN) rate, incidence of axillary nodal metastases, or the number of SLN identified. Methods: In this prospective multi-institutional study, SLN biopsy was performed on clinical stage T1-2, NO breast cancer patients using blue dye alone or in combination with radioactive colloid, followed by completion axillary LN dissection. Results: Central tumor location was associated with an improved FN rate, which may be related to reliable drainage from the subareolar lymphatic plexus. Tumor location did not significantly affect the SLN ID rate or the mean number of SLN identified. Medial tumor location was associated with a decreased rate of axillary nodal metastasis. Conclusions: Breast cancers drain reliably to the axillary lymph nodes regardless of tumor location within the breast.

Original languageEnglish (US)
Pages (from-to)307-311
Number of pages5
JournalAmerican Journal of Surgery
Volume182
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Drainage
Breast
Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Sentinel Lymph Node Biopsy
Colloids
Dissection
Coloring Agents
Lymph Nodes
Sentinel Lymph Node
Incidence

Keywords

  • Axillary metastases
  • Breast cancer
  • Sentinel lymph node biopsy
  • Tumor location

ASJC Scopus subject areas

  • Surgery

Cite this

Reliable lymphatic drainage to axillary sentinel lymph nodes regardless of tumor location within the breast. / Chao, Celia; Wong, Sandra L.; Woo, Claudine; Edwards, Michael J.; Turtle, Todd; Noyes, R. Dirk; Carlson, David J.; Turk, Peter; Simpson, Diana; McMasters, Kelly M.

In: American Journal of Surgery, Vol. 182, No. 4, 2001, p. 307-311.

Research output: Contribution to journalArticle

Chao, C, Wong, SL, Woo, C, Edwards, MJ, Turtle, T, Noyes, RD, Carlson, DJ, Turk, P, Simpson, D & McMasters, KM 2001, 'Reliable lymphatic drainage to axillary sentinel lymph nodes regardless of tumor location within the breast', American Journal of Surgery, vol. 182, no. 4, pp. 307-311. https://doi.org/10.1016/S0002-9610(01)00717-6
Chao, Celia ; Wong, Sandra L. ; Woo, Claudine ; Edwards, Michael J. ; Turtle, Todd ; Noyes, R. Dirk ; Carlson, David J. ; Turk, Peter ; Simpson, Diana ; McMasters, Kelly M. / Reliable lymphatic drainage to axillary sentinel lymph nodes regardless of tumor location within the breast. In: American Journal of Surgery. 2001 ; Vol. 182, No. 4. pp. 307-311.
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AU - Chao, Celia

AU - Wong, Sandra L.

AU - Woo, Claudine

AU - Edwards, Michael J.

AU - Turtle, Todd

AU - Noyes, R. Dirk

AU - Carlson, David J.

AU - Turk, Peter

AU - Simpson, Diana

AU - McMasters, Kelly M.

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N2 - Background: This analysis was performed in order to determine whether primary tumor location in breast cancer affects the axillary sentinel lymph node (SLN) identification (ID) rate, the false negative (FN) rate, incidence of axillary nodal metastases, or the number of SLN identified. Methods: In this prospective multi-institutional study, SLN biopsy was performed on clinical stage T1-2, NO breast cancer patients using blue dye alone or in combination with radioactive colloid, followed by completion axillary LN dissection. Results: Central tumor location was associated with an improved FN rate, which may be related to reliable drainage from the subareolar lymphatic plexus. Tumor location did not significantly affect the SLN ID rate or the mean number of SLN identified. Medial tumor location was associated with a decreased rate of axillary nodal metastasis. Conclusions: Breast cancers drain reliably to the axillary lymph nodes regardless of tumor location within the breast.

AB - Background: This analysis was performed in order to determine whether primary tumor location in breast cancer affects the axillary sentinel lymph node (SLN) identification (ID) rate, the false negative (FN) rate, incidence of axillary nodal metastases, or the number of SLN identified. Methods: In this prospective multi-institutional study, SLN biopsy was performed on clinical stage T1-2, NO breast cancer patients using blue dye alone or in combination with radioactive colloid, followed by completion axillary LN dissection. Results: Central tumor location was associated with an improved FN rate, which may be related to reliable drainage from the subareolar lymphatic plexus. Tumor location did not significantly affect the SLN ID rate or the mean number of SLN identified. Medial tumor location was associated with a decreased rate of axillary nodal metastasis. Conclusions: Breast cancers drain reliably to the axillary lymph nodes regardless of tumor location within the breast.

KW - Axillary metastases

KW - Breast cancer

KW - Sentinel lymph node biopsy

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