Abstract
Metastases to the thyroid gland are a common finding at autopsy in patients who died of malignancy and are often misdiagnosed as primary thyroid neoplasms clinically. We present a patient with a rare, unusual case of renal cell carcinoma (RCC) metastatic to a Hürthle cell adenoma of the thyroid. A 53-year-old woman was admitted to a University of Texas Medical Branch Hospital (Galveston, TX) for a large right thyroid mass that was present for 3 months. A fine needle aspiration of the thyroid mass was performed and interpreted as suggestive of a Hürthle cell neoplasm. A total thyroidectomy revealed Hürthle cell adenoma containing clusters of cytologically atypical cells with clear cytoplasm. Subsequent patient evaluation and computed tomography revealed a renal mass. Left radical nephrectomy was performed at a later date for left renal mass and the microscopic examination confirmed the diagnosis of primary clear cell carcinoma of the kidney. Further studies confirmed that the thyroid mass was metastases from RCC. Although carcinoma of the kidney is responsible in most instances of metastatic disease to the thyroid, metastatic RCC to a thyroid neoplasm is extremely rare, with only two reports found in the English literature. The possibility of metastatic RCC should always be taken under consideration, especially when nests of clear cells are seen infiltrating into the thyroid parenchyma or neoplasm.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 305-308 |
| Number of pages | 4 |
| Journal | Annals of Diagnostic Pathology |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 2004 |
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Keywords
- Hürthle cell adenoma
- Metastatic disease
- renal cell carcinoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Renal cell carcinoma metastatic to Hürthle cell adenoma of thyroid. / Qian, Lian; Pucci, Richard; Castro, Claudia Y.; Eltorky, Mahmoud A.
In: Annals of Diagnostic Pathology, Vol. 8, No. 5, 10.2004, p. 305-308.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Renal cell carcinoma metastatic to Hürthle cell adenoma of thyroid
AU - Qian, Lian
AU - Pucci, Richard
AU - Castro, Claudia Y.
AU - Eltorky, Mahmoud A.
PY - 2004/10
Y1 - 2004/10
N2 - Metastases to the thyroid gland are a common finding at autopsy in patients who died of malignancy and are often misdiagnosed as primary thyroid neoplasms clinically. We present a patient with a rare, unusual case of renal cell carcinoma (RCC) metastatic to a Hürthle cell adenoma of the thyroid. A 53-year-old woman was admitted to a University of Texas Medical Branch Hospital (Galveston, TX) for a large right thyroid mass that was present for 3 months. A fine needle aspiration of the thyroid mass was performed and interpreted as suggestive of a Hürthle cell neoplasm. A total thyroidectomy revealed Hürthle cell adenoma containing clusters of cytologically atypical cells with clear cytoplasm. Subsequent patient evaluation and computed tomography revealed a renal mass. Left radical nephrectomy was performed at a later date for left renal mass and the microscopic examination confirmed the diagnosis of primary clear cell carcinoma of the kidney. Further studies confirmed that the thyroid mass was metastases from RCC. Although carcinoma of the kidney is responsible in most instances of metastatic disease to the thyroid, metastatic RCC to a thyroid neoplasm is extremely rare, with only two reports found in the English literature. The possibility of metastatic RCC should always be taken under consideration, especially when nests of clear cells are seen infiltrating into the thyroid parenchyma or neoplasm.
AB - Metastases to the thyroid gland are a common finding at autopsy in patients who died of malignancy and are often misdiagnosed as primary thyroid neoplasms clinically. We present a patient with a rare, unusual case of renal cell carcinoma (RCC) metastatic to a Hürthle cell adenoma of the thyroid. A 53-year-old woman was admitted to a University of Texas Medical Branch Hospital (Galveston, TX) for a large right thyroid mass that was present for 3 months. A fine needle aspiration of the thyroid mass was performed and interpreted as suggestive of a Hürthle cell neoplasm. A total thyroidectomy revealed Hürthle cell adenoma containing clusters of cytologically atypical cells with clear cytoplasm. Subsequent patient evaluation and computed tomography revealed a renal mass. Left radical nephrectomy was performed at a later date for left renal mass and the microscopic examination confirmed the diagnosis of primary clear cell carcinoma of the kidney. Further studies confirmed that the thyroid mass was metastases from RCC. Although carcinoma of the kidney is responsible in most instances of metastatic disease to the thyroid, metastatic RCC to a thyroid neoplasm is extremely rare, with only two reports found in the English literature. The possibility of metastatic RCC should always be taken under consideration, especially when nests of clear cells are seen infiltrating into the thyroid parenchyma or neoplasm.
KW - Hürthle cell adenoma
KW - Metastatic disease
KW - renal cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=5644244785&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=5644244785&partnerID=8YFLogxK
U2 - 10.1016/j.anndiagpath.2004.07.011
DO - 10.1016/j.anndiagpath.2004.07.011
M3 - Article
C2 - 15494939
AN - SCOPUS:5644244785
VL - 8
SP - 305
EP - 308
JO - Annals of Diagnostic Pathology
JF - Annals of Diagnostic Pathology
SN - 1092-9134
IS - 5
ER -