Renal function in children undergoing cardiac operations

E. N. Ellis, B. H. Brouhard, Vincent Conti

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Because we sometimes observed large amounts of uric acid crystals in the urine of infants and children after open-heart operations and since renal insufficiency from any cause can be a serious complication of cardiac procedures, 8 acyanotic and 5 cyanotic children were studied prospectively by comparing several preoperative and postoperative measures of renal function. There were no significant differences between the acyanotic and cyanotic groups in terms of age, time on cardiopulmonary bypass, or other preoperative variables. Postoperatively, children in both groups had a wide range of free water clearances (C(H2O)), with some values in the range reported to be diagnostic of renal insufficiency in adults. Since none of these children had renal insufficiency by other criteria, C(H2O) may not be as reliable an indicator of renal insufficiency in children. The major difference between the cyanotic and acyanotic groups was seen in postoperative serum uric acid levels (S(UA)); the mean S(UA) levels in the acyanotic and cyanotic groups were 5.3 ± 0.5 mg/dl (± standard error of the mean) and 10.4 ± 1.7 mg/dl (range, 8.0 to 15.5 mg/dl), respectively. Since the hyperuricemia in the cyanotic children could not be related to increased exogenous administration or decreased renal excretion, it is probably caused by increased endogenous production and may be related to the resolution of the cyanotic state.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalAnnals of Thoracic Surgery
Volume36
Issue number2
StatePublished - 1983

Fingerprint

Kidney
Renal Insufficiency
Uric Acid
Hyperuricemia
Serum
Cardiopulmonary Bypass
Urine
Water

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Renal function in children undergoing cardiac operations. / Ellis, E. N.; Brouhard, B. H.; Conti, Vincent.

In: Annals of Thoracic Surgery, Vol. 36, No. 2, 1983, p. 167-172.

Research output: Contribution to journalArticle

Ellis, EN, Brouhard, BH & Conti, V 1983, 'Renal function in children undergoing cardiac operations', Annals of Thoracic Surgery, vol. 36, no. 2, pp. 167-172.
Ellis, E. N. ; Brouhard, B. H. ; Conti, Vincent. / Renal function in children undergoing cardiac operations. In: Annals of Thoracic Surgery. 1983 ; Vol. 36, No. 2. pp. 167-172.
@article{ca155e9c84614bf0ad0671087d5d171f,
title = "Renal function in children undergoing cardiac operations",
abstract = "Because we sometimes observed large amounts of uric acid crystals in the urine of infants and children after open-heart operations and since renal insufficiency from any cause can be a serious complication of cardiac procedures, 8 acyanotic and 5 cyanotic children were studied prospectively by comparing several preoperative and postoperative measures of renal function. There were no significant differences between the acyanotic and cyanotic groups in terms of age, time on cardiopulmonary bypass, or other preoperative variables. Postoperatively, children in both groups had a wide range of free water clearances (C(H2O)), with some values in the range reported to be diagnostic of renal insufficiency in adults. Since none of these children had renal insufficiency by other criteria, C(H2O) may not be as reliable an indicator of renal insufficiency in children. The major difference between the cyanotic and acyanotic groups was seen in postoperative serum uric acid levels (S(UA)); the mean S(UA) levels in the acyanotic and cyanotic groups were 5.3 ± 0.5 mg/dl (± standard error of the mean) and 10.4 ± 1.7 mg/dl (range, 8.0 to 15.5 mg/dl), respectively. Since the hyperuricemia in the cyanotic children could not be related to increased exogenous administration or decreased renal excretion, it is probably caused by increased endogenous production and may be related to the resolution of the cyanotic state.",
author = "Ellis, {E. N.} and Brouhard, {B. H.} and Vincent Conti",
year = "1983",
language = "English (US)",
volume = "36",
pages = "167--172",
journal = "Annals of Thoracic Surgery",
issn = "0003-4975",
publisher = "Elsevier USA",
number = "2",

}

TY - JOUR

T1 - Renal function in children undergoing cardiac operations

AU - Ellis, E. N.

AU - Brouhard, B. H.

AU - Conti, Vincent

PY - 1983

Y1 - 1983

N2 - Because we sometimes observed large amounts of uric acid crystals in the urine of infants and children after open-heart operations and since renal insufficiency from any cause can be a serious complication of cardiac procedures, 8 acyanotic and 5 cyanotic children were studied prospectively by comparing several preoperative and postoperative measures of renal function. There were no significant differences between the acyanotic and cyanotic groups in terms of age, time on cardiopulmonary bypass, or other preoperative variables. Postoperatively, children in both groups had a wide range of free water clearances (C(H2O)), with some values in the range reported to be diagnostic of renal insufficiency in adults. Since none of these children had renal insufficiency by other criteria, C(H2O) may not be as reliable an indicator of renal insufficiency in children. The major difference between the cyanotic and acyanotic groups was seen in postoperative serum uric acid levels (S(UA)); the mean S(UA) levels in the acyanotic and cyanotic groups were 5.3 ± 0.5 mg/dl (± standard error of the mean) and 10.4 ± 1.7 mg/dl (range, 8.0 to 15.5 mg/dl), respectively. Since the hyperuricemia in the cyanotic children could not be related to increased exogenous administration or decreased renal excretion, it is probably caused by increased endogenous production and may be related to the resolution of the cyanotic state.

AB - Because we sometimes observed large amounts of uric acid crystals in the urine of infants and children after open-heart operations and since renal insufficiency from any cause can be a serious complication of cardiac procedures, 8 acyanotic and 5 cyanotic children were studied prospectively by comparing several preoperative and postoperative measures of renal function. There were no significant differences between the acyanotic and cyanotic groups in terms of age, time on cardiopulmonary bypass, or other preoperative variables. Postoperatively, children in both groups had a wide range of free water clearances (C(H2O)), with some values in the range reported to be diagnostic of renal insufficiency in adults. Since none of these children had renal insufficiency by other criteria, C(H2O) may not be as reliable an indicator of renal insufficiency in children. The major difference between the cyanotic and acyanotic groups was seen in postoperative serum uric acid levels (S(UA)); the mean S(UA) levels in the acyanotic and cyanotic groups were 5.3 ± 0.5 mg/dl (± standard error of the mean) and 10.4 ± 1.7 mg/dl (range, 8.0 to 15.5 mg/dl), respectively. Since the hyperuricemia in the cyanotic children could not be related to increased exogenous administration or decreased renal excretion, it is probably caused by increased endogenous production and may be related to the resolution of the cyanotic state.

UR - http://www.scopus.com/inward/record.url?scp=0020561960&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020561960&partnerID=8YFLogxK

M3 - Article

C2 - 6882075

AN - SCOPUS:0020561960

VL - 36

SP - 167

EP - 172

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

IS - 2

ER -