Renal involvement in Behcet's disease.

Mohammad Reza Ardalan, Shahram Sadreddini, Hamid Noshad, Aliasghar Ebrahimi, Mahsheed Molaeefard, Mohammad Hossein Somi, Mohammadali Mohajel Shoja

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

There are conflicting reports about the renal involvement in Behcet's disease (BD). In this study we aimed to study the frequency and type of renal involvement in a group of patients with BD in Azerbaijan province that is one of the prevalent areas of BD in Iran. All cases of BD were prospectively followed between June 2004 and January 2007, and evaluated for renal dys-function (serum creatinine > 1.7 mg/dL), glomerular hematuria and proteinuria. Those patients with proteinuria > 500 mg/day and serum creatinine level > 2 mg/dL, underwent renal biopsy. From a total number of 100 patients, six patients (6%) had obvious renal involvements. Four patients had glomerular hematuria and proteinuria. Renal biopsy in two of them revealed measangial proliferative glumerulonephritis with IgA deposit in one of them and membranoproliferative glumerolonephritis in another one. Two remaining patients had serum creatinine > 2 mg/dL without any hematuria or proteinuria. Serologic study for viral agents and collagen vascular disease were negative in all patients with renal involvements. In conclusion, renal involvement in BD is not infrequent, although in most cases it is mild in nature and may be missed.

Original languageEnglish (US)
Pages (from-to)618-622
Number of pages5
JournalSaudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Volume20
Issue number4
StatePublished - Jan 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Ardalan, M. R., Sadreddini, S., Noshad, H., Ebrahimi, A., Molaeefard, M., Somi, M. H., & Mohajel Shoja, M. (2009). Renal involvement in Behcet's disease. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 20(4), 618-622.