Renal Replacement Therapy in Severe Burns: A Multicenter Observational Study

Kevin K. Chung, Elsa C. Coates, William L. Hickerson, Angela L. Arnold-Ross, Daniel M. Caruso, Marlene Albrecht, Brett D. Arnoldo, Christina Howard, Laura S. Johnson, Melissa M. McLawhorn, Bruce Friedman, Amy M. Sprague, Michael J. Mosier, David J. Smith, Rachel A. Karlnoski, James K. Aden, Elizabeth A. Mann-Salinas, Steven E. Wolf

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Acute kidney injury (AKI) after severe burns is historically associated with a high mortality. Over the past two decades, various modes of renal replacement therapy (RRT) have been used in this population. The purpose of this multicenter study was to evaluate demographic, treatment, and outcomes data among severe burn patients treated with RRT collectively at various burn centers around the United States. After institutional review board approval, a multicenter observational study was conducted. All adult patients aged 18 or older, admitted with severe burns who were placed on RRT for acute indications but not randomized into a concurrently enrolling interventional trial, were included. Across eight participating burn centers, 171 subjects were enrolled during a 4-year period. Complete data were available in 170 subjects with a mean age of 51 ± 17, percent total body surface area burn of 38 ± 26% and injury severity score of 27 ± 21. Eighty percent of subjects were male and 34% were diagnosed with smoke inhalation injury. The preferred mode of therapy was continuous venovenous hemofiltration at a mean delivered dose of 37 ± 19 (ml/kg/hour) and a treatment duration of 13 ± 24 days. Overall, in hospital, mortality was 50%. Among survivors, 21% required RRT on discharge from the hospital while 9% continued to require RRT 6 months after discharge. This is the first multicenter cohort of burn patients who underwent RRT reported to date. Overall mortality is comparable to other critically ill populations who undergo RRT. Most patients who survive to discharge eventually recover renal function.

Original languageEnglish (US)
Pages (from-to)1017-1021
Number of pages5
JournalJournal of Burn Care and Research
Volume39
Issue number6
DOIs
StatePublished - Oct 23 2018

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Rehabilitation

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    Chung, K. K., Coates, E. C., Hickerson, W. L., Arnold-Ross, A. L., Caruso, D. M., Albrecht, M., Arnoldo, B. D., Howard, C., Johnson, L. S., McLawhorn, M. M., Friedman, B., Sprague, A. M., Mosier, M. J., Smith, D. J., Karlnoski, R. A., Aden, J. K., Mann-Salinas, E. A., & Wolf, S. E. (2018). Renal Replacement Therapy in Severe Burns: A Multicenter Observational Study. Journal of Burn Care and Research, 39(6), 1017-1021. https://doi.org/10.1093/jbcr/iry036