Renal transplantation following previous heart, liver, and lung transplantation: An 8-year single-center experience

C. M. Coopersmith, D. C. Brennan, B. Miller, C. Wang, P. Hmiel, S. Shenoy, V. Ramachandran, M. D. Jendrisak, C. S. Ceriotti, T. Mohanakumar, J. A. Lowell

    Research output: Contribution to journalArticle

    29 Citations (Scopus)

    Abstract

    Background. Long-term follow-up of heart, liver, and lung transplantation has led to an increased recognition of secondary end-stage renal failure (ESRF) in transplant recipients. This study examines our center's experience with renal transplantation following previous solid organ transplantation. Methods. From January 1, 1992, to September 30, 1999, our center performed 18 renal transplants in previous solid organ recipients. During the same period, 815 total renal transplants were performed. One- and 3-year graft and patient survival, recipient demographics, donor type, and reason for transplantation were compared between these groups. Results. Of the 18 recipients, 7 had prior heart transplants, 4 had prior liver transplants, and 7 had prior lung transplants. Cyclosporine toxicity contributed to renal failure in 17 (94.4%) of the patients - either as a sole factor (11 patients) or in combination with hypertension, renal artery stenosis, or tacrolimus toxicity (6 patients). Kaplan-Meier 1- and 3-year patient survival was 82.9% and 73.7%, compared with 95.5 % and 90.7% in all renal transplant recipients. No surviving patient has suffered renal allograft loss. Mean current creatinine level is 1.4 mg/dL. Conclusions. Renal transplantation is an excellent therapy for ESRF following prior solid organ transplantation. One and 3-year patient and graft survival demonstrate the utility of renal transplantation in this patient population.

    Original languageEnglish (US)
    Pages (from-to)457-462
    Number of pages6
    JournalSurgery
    Volume130
    Issue number3
    DOIs
    StatePublished - 2001

    Fingerprint

    Heart-Lung Transplantation
    Liver Transplantation
    Kidney Transplantation
    Transplants
    Kidney
    Organ Transplantation
    Graft Survival
    Chronic Kidney Failure
    Renal Artery Obstruction
    Tacrolimus
    Cyclosporine
    Renal Insufficiency
    Allografts
    Creatinine
    Transplantation
    Demography
    Tissue Donors
    Hypertension
    Lung
    Survival

    ASJC Scopus subject areas

    • Surgery

    Cite this

    Coopersmith, C. M., Brennan, D. C., Miller, B., Wang, C., Hmiel, P., Shenoy, S., ... Lowell, J. A. (2001). Renal transplantation following previous heart, liver, and lung transplantation: An 8-year single-center experience. Surgery, 130(3), 457-462. https://doi.org/10.1067/msy.2001.115834

    Renal transplantation following previous heart, liver, and lung transplantation : An 8-year single-center experience. / Coopersmith, C. M.; Brennan, D. C.; Miller, B.; Wang, C.; Hmiel, P.; Shenoy, S.; Ramachandran, V.; Jendrisak, M. D.; Ceriotti, C. S.; Mohanakumar, T.; Lowell, J. A.

    In: Surgery, Vol. 130, No. 3, 2001, p. 457-462.

    Research output: Contribution to journalArticle

    Coopersmith, CM, Brennan, DC, Miller, B, Wang, C, Hmiel, P, Shenoy, S, Ramachandran, V, Jendrisak, MD, Ceriotti, CS, Mohanakumar, T & Lowell, JA 2001, 'Renal transplantation following previous heart, liver, and lung transplantation: An 8-year single-center experience', Surgery, vol. 130, no. 3, pp. 457-462. https://doi.org/10.1067/msy.2001.115834
    Coopersmith, C. M. ; Brennan, D. C. ; Miller, B. ; Wang, C. ; Hmiel, P. ; Shenoy, S. ; Ramachandran, V. ; Jendrisak, M. D. ; Ceriotti, C. S. ; Mohanakumar, T. ; Lowell, J. A. / Renal transplantation following previous heart, liver, and lung transplantation : An 8-year single-center experience. In: Surgery. 2001 ; Vol. 130, No. 3. pp. 457-462.
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    abstract = "Background. Long-term follow-up of heart, liver, and lung transplantation has led to an increased recognition of secondary end-stage renal failure (ESRF) in transplant recipients. This study examines our center's experience with renal transplantation following previous solid organ transplantation. Methods. From January 1, 1992, to September 30, 1999, our center performed 18 renal transplants in previous solid organ recipients. During the same period, 815 total renal transplants were performed. One- and 3-year graft and patient survival, recipient demographics, donor type, and reason for transplantation were compared between these groups. Results. Of the 18 recipients, 7 had prior heart transplants, 4 had prior liver transplants, and 7 had prior lung transplants. Cyclosporine toxicity contributed to renal failure in 17 (94.4{\%}) of the patients - either as a sole factor (11 patients) or in combination with hypertension, renal artery stenosis, or tacrolimus toxicity (6 patients). Kaplan-Meier 1- and 3-year patient survival was 82.9{\%} and 73.7{\%}, compared with 95.5 {\%} and 90.7{\%} in all renal transplant recipients. No surviving patient has suffered renal allograft loss. Mean current creatinine level is 1.4 mg/dL. Conclusions. Renal transplantation is an excellent therapy for ESRF following prior solid organ transplantation. One and 3-year patient and graft survival demonstrate the utility of renal transplantation in this patient population.",
    author = "Coopersmith, {C. M.} and Brennan, {D. C.} and B. Miller and C. Wang and P. Hmiel and S. Shenoy and V. Ramachandran and Jendrisak, {M. D.} and Ceriotti, {C. S.} and T. Mohanakumar and Lowell, {J. A.}",
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    T1 - Renal transplantation following previous heart, liver, and lung transplantation

    T2 - An 8-year single-center experience

    AU - Coopersmith, C. M.

    AU - Brennan, D. C.

    AU - Miller, B.

    AU - Wang, C.

    AU - Hmiel, P.

    AU - Shenoy, S.

    AU - Ramachandran, V.

    AU - Jendrisak, M. D.

    AU - Ceriotti, C. S.

    AU - Mohanakumar, T.

    AU - Lowell, J. A.

    PY - 2001

    Y1 - 2001

    N2 - Background. Long-term follow-up of heart, liver, and lung transplantation has led to an increased recognition of secondary end-stage renal failure (ESRF) in transplant recipients. This study examines our center's experience with renal transplantation following previous solid organ transplantation. Methods. From January 1, 1992, to September 30, 1999, our center performed 18 renal transplants in previous solid organ recipients. During the same period, 815 total renal transplants were performed. One- and 3-year graft and patient survival, recipient demographics, donor type, and reason for transplantation were compared between these groups. Results. Of the 18 recipients, 7 had prior heart transplants, 4 had prior liver transplants, and 7 had prior lung transplants. Cyclosporine toxicity contributed to renal failure in 17 (94.4%) of the patients - either as a sole factor (11 patients) or in combination with hypertension, renal artery stenosis, or tacrolimus toxicity (6 patients). Kaplan-Meier 1- and 3-year patient survival was 82.9% and 73.7%, compared with 95.5 % and 90.7% in all renal transplant recipients. No surviving patient has suffered renal allograft loss. Mean current creatinine level is 1.4 mg/dL. Conclusions. Renal transplantation is an excellent therapy for ESRF following prior solid organ transplantation. One and 3-year patient and graft survival demonstrate the utility of renal transplantation in this patient population.

    AB - Background. Long-term follow-up of heart, liver, and lung transplantation has led to an increased recognition of secondary end-stage renal failure (ESRF) in transplant recipients. This study examines our center's experience with renal transplantation following previous solid organ transplantation. Methods. From January 1, 1992, to September 30, 1999, our center performed 18 renal transplants in previous solid organ recipients. During the same period, 815 total renal transplants were performed. One- and 3-year graft and patient survival, recipient demographics, donor type, and reason for transplantation were compared between these groups. Results. Of the 18 recipients, 7 had prior heart transplants, 4 had prior liver transplants, and 7 had prior lung transplants. Cyclosporine toxicity contributed to renal failure in 17 (94.4%) of the patients - either as a sole factor (11 patients) or in combination with hypertension, renal artery stenosis, or tacrolimus toxicity (6 patients). Kaplan-Meier 1- and 3-year patient survival was 82.9% and 73.7%, compared with 95.5 % and 90.7% in all renal transplant recipients. No surviving patient has suffered renal allograft loss. Mean current creatinine level is 1.4 mg/dL. Conclusions. Renal transplantation is an excellent therapy for ESRF following prior solid organ transplantation. One and 3-year patient and graft survival demonstrate the utility of renal transplantation in this patient population.

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