Repair of potentially lethal radiation damage in confluent and non-confluent cultures of human hybrid cells

C. Sun, J. L. Redpath, M. Colman, E. J. Stanbridge

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The repair of potentially lethal damage (PLDR) in a gamma-irradiated human hybrid cell line (skin fibroblast × HeLa) and its tumourigenic segregant has been studied as a function of cell density at the time of irradiation and during the post-irradiation repair period. The data show that PLDR occurs in both non-confluent and confluent cultures of both cell lines. Furthermore, there is evidence that the extent of PLDR is dependent on cell density and that cell-cell contact may be an important factor in this regard.

Original languageEnglish (US)
Pages (from-to)395-402
Number of pages8
JournalInternational Journal of Radiation Biology
Volume49
Issue number3
DOIs
StatePublished - 1985
Externally publishedYes

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Keywords

  • Cell density
  • Human hybrid cells
  • Potentially lethal damage repair

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Agricultural and Biological Sciences (miscellaneous)
  • Nuclear Energy and Engineering
  • Radiation

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