Repair of potentially lethal radiation damage in confluent and non-confluent cultures of human hybrid cells

C. Sun; J. L. Redpath; M. Colman; E. J. Stanbridge

doi:10.1080/09553008514552621

Repair of potentially lethal radiation damage in confluent and non-confluent cultures of human hybrid cells

C. Sun, J. L. Redpath, M. Colman, E. J. Stanbridge

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The repair of potentially lethal damage (PLDR) in a gamma-irradiated human hybrid cell line (skin fibroblast × HeLa) and its tumourigenic segregant has been studied as a function of cell density at the time of irradiation and during the post-irradiation repair period. The data show that PLDR occurs in both non-confluent and confluent cultures of both cell lines. Furthermore, there is evidence that the extent of PLDR is dependent on cell density and that cell-cell contact may be an important factor in this regard.

Original language	English (US)
Pages (from-to)	395-402
Number of pages	8
Journal	International Journal of Radiation Biology
Volume	49
Issue number	3
DOIs	https://doi.org/10.1080/09553008514552621
State	Published - 1985
Externally published	Yes

Keywords

Cell density
Human hybrid cells
Potentially lethal damage repair

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging

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10.1080/09553008514552621

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title = "Repair of potentially lethal radiation damage in confluent and non-confluent cultures of human hybrid cells",

abstract = "The repair of potentially lethal damage (PLDR) in a gamma-irradiated human hybrid cell line (skin fibroblast × HeLa) and its tumourigenic segregant has been studied as a function of cell density at the time of irradiation and during the post-irradiation repair period. The data show that PLDR occurs in both non-confluent and confluent cultures of both cell lines. Furthermore, there is evidence that the extent of PLDR is dependent on cell density and that cell-cell contact may be an important factor in this regard.",

keywords = "Cell density, Human hybrid cells, Potentially lethal damage repair",

author = "C. Sun and Redpath, {J. L.} and M. Colman and Stanbridge, {E. J.}",

note = "Funding Information: This work was supported by Phi Beta Psi Sorority and in part by NIH Grant CA",

year = "1985",

doi = "10.1080/09553008514552621",

language = "English (US)",

volume = "49",

pages = "395--402",

journal = "International Journal of Radiation Biology",

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T1 - Repair of potentially lethal radiation damage in confluent and non-confluent cultures of human hybrid cells

AU - Sun, C.

AU - Redpath, J. L.

AU - Colman, M.

AU - Stanbridge, E. J.

N1 - Funding Information: This work was supported by Phi Beta Psi Sorority and in part by NIH Grant CA

PY - 1985

Y1 - 1985

N2 - The repair of potentially lethal damage (PLDR) in a gamma-irradiated human hybrid cell line (skin fibroblast × HeLa) and its tumourigenic segregant has been studied as a function of cell density at the time of irradiation and during the post-irradiation repair period. The data show that PLDR occurs in both non-confluent and confluent cultures of both cell lines. Furthermore, there is evidence that the extent of PLDR is dependent on cell density and that cell-cell contact may be an important factor in this regard.

AB - The repair of potentially lethal damage (PLDR) in a gamma-irradiated human hybrid cell line (skin fibroblast × HeLa) and its tumourigenic segregant has been studied as a function of cell density at the time of irradiation and during the post-irradiation repair period. The data show that PLDR occurs in both non-confluent and confluent cultures of both cell lines. Furthermore, there is evidence that the extent of PLDR is dependent on cell density and that cell-cell contact may be an important factor in this regard.

KW - Cell density

KW - Human hybrid cells

KW - Potentially lethal damage repair

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AN - SCOPUS:0022634975

SN - 0955-3002

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JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

IS - 3

ER -

Repair of potentially lethal radiation damage in confluent and non-confluent cultures of human hybrid cells

Abstract

Keywords

ASJC Scopus subject areas

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