Repair of potentially lethal radiation damage in confluent and non-confluent cultures of human hybrid cells

C. Sun, J. L. Redpath, M. Colman, E. J. Stanbridge

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The repair of potentially lethal damage (PLDR) in a gamma-irradiated human hybrid cell line (skin fibroblast × HeLa) and its tumourigenic segregant has been studied as a function of cell density at the time of irradiation and during the post-irradiation repair period. The data show that PLDR occurs in both non-confluent and confluent cultures of both cell lines. Furthermore, there is evidence that the extent of PLDR is dependent on cell density and that cell-cell contact may be an important factor in this regard.

Original languageEnglish (US)
Pages (from-to)395-402
Number of pages8
JournalInternational Journal of Radiation Biology
Volume49
Issue number3
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Hybrid Cells
Radiation damage
radiation damage
Repair
Cell Count
Cells
Irradiation
Radiation
Cell Line
Fibroblasts
cells
Cell culture
cultured cells
Skin
irradiation
cell lines
fibroblasts
skin (animal)
damage

Keywords

  • Cell density
  • Human hybrid cells
  • Potentially lethal damage repair

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Agricultural and Biological Sciences (miscellaneous)
  • Nuclear Energy and Engineering
  • Radiation

Cite this

Repair of potentially lethal radiation damage in confluent and non-confluent cultures of human hybrid cells. / Sun, C.; Redpath, J. L.; Colman, M.; Stanbridge, E. J.

In: International Journal of Radiation Biology, Vol. 49, No. 3, 1985, p. 395-402.

Research output: Contribution to journalArticle

Sun, C. ; Redpath, J. L. ; Colman, M. ; Stanbridge, E. J. / Repair of potentially lethal radiation damage in confluent and non-confluent cultures of human hybrid cells. In: International Journal of Radiation Biology. 1985 ; Vol. 49, No. 3. pp. 395-402.
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