Repeated cocaine administration does not affect 5-HT receptor subtypes (5-HT1A, 5-HT2) in several rat brain regions

Javaid I. Javaid, Sanjeev K. Sahni, Subhash C. Pandey, John M. Davis

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

In order to examine whether cocaine-induced behavioral sensitization is modulated by changes in serotonin receptor subtypes, we measured the binding of [3H]8-hydroxy-2-(di-n-propylamino)tetralin (3H]8-OH-DPAT) to 5-HT1A receptors and of [3H]-ketanserin to 5-HT2 receptors in various brain regions of cocaine-treated and saline-treated (control) rats. As previously reported, repeated administration of cocaine resulted in behavioral sensitization. Stereotypic scores with the cocaine challenge were significantly (P < 0.05) higher in cocaine-pretreated animals than in the saline-pretreated group. Neither acute nor chronic cocaine administration significantly altered the number (Bmax) or the affinity (KD) of either [3H]8-OH-DPAT or [3H]ketanserin binding sites in any of the brain regions examined. These results suggest that the enhanced functional sensitivity of 5-HT1A or 5-HT2 receptor subtypes seen with cocaine may be associated with alterations in processes distal to receptors rather than changes in the number or the affinity of the receptors.

Original languageEnglish (US)
Pages (from-to)425-429
Number of pages5
JournalEuropean Journal of Pharmacology
Volume238
Issue number2-3
DOIs
StatePublished - Jul 20 1993
Externally publishedYes

Keywords

  • 5-HT receptors
  • 5-HT receptors
  • Brain regions (rat)
  • Cocaine

ASJC Scopus subject areas

  • Pharmacology

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