Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats

Emily D. Klein, Brenda J. Gehrke, Thomas A. Green, Thomas R. Zentall, Michael T. Bardo

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The purpose of the present experiment was to determine whether repeated cocaine exposure differentially affects sucrose-reinforced operant responding in rats raised in an enriched condition (EC) or an isolated condition (IC). Specifically, the performance of EC and IC rats pressing a lever for sucrose under a high fixed-ratio schedule (FR 30) prior to and after 10 days of exposure to cocaine (15 mg/kg, i.p.) or saline was compared. Regardless of rearing condition, rats repeatedly exposed to cocaine had shorter reacquisition latencies to complete a sucrose-reinforced FR 30 task than saline controls. The results suggest that cocaine exposure may have cross-sensitized both EC and IC rats to the reinforcing effects of sucrose or sucrose-associated cues, thus facilitating reacquisition of operant responding.

Original languageEnglish (US)
Pages (from-to)44-55
Number of pages12
JournalLearning and Motivation
Issue number1
StatePublished - Feb 2007
Externally publishedYes


  • Cocaine
  • Environmental enrichment
  • Fixed ratio
  • Locomotor
  • Sensitization
  • Sucrose

ASJC Scopus subject areas

  • Health(social science)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Education
  • Developmental and Educational Psychology

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