Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats

Emily D. Klein, Brenda J. Gehrke, Thomas Green, Thomas R. Zentall, Michael T. Bardo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The purpose of the present experiment was to determine whether repeated cocaine exposure differentially affects sucrose-reinforced operant responding in rats raised in an enriched condition (EC) or an isolated condition (IC). Specifically, the performance of EC and IC rats pressing a lever for sucrose under a high fixed-ratio schedule (FR 30) prior to and after 10 days of exposure to cocaine (15 mg/kg, i.p.) or saline was compared. Regardless of rearing condition, rats repeatedly exposed to cocaine had shorter reacquisition latencies to complete a sucrose-reinforced FR 30 task than saline controls. The results suggest that cocaine exposure may have cross-sensitized both EC and IC rats to the reinforcing effects of sucrose or sucrose-associated cues, thus facilitating reacquisition of operant responding.

Original languageEnglish (US)
Pages (from-to)44-55
Number of pages12
JournalLearning and Motivation
Volume38
Issue number1
DOIs
StatePublished - Feb 2007
Externally publishedYes

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Cocaine
Sucrose
experiment
performance
experience
Cues
Appointments and Schedules

Keywords

  • Cocaine
  • Environmental enrichment
  • Fixed ratio
  • Locomotor
  • Sensitization
  • Sucrose

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Developmental and Educational Psychology
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology

Cite this

Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats. / Klein, Emily D.; Gehrke, Brenda J.; Green, Thomas; Zentall, Thomas R.; Bardo, Michael T.

In: Learning and Motivation, Vol. 38, No. 1, 02.2007, p. 44-55.

Research output: Contribution to journalArticle

Klein, Emily D. ; Gehrke, Brenda J. ; Green, Thomas ; Zentall, Thomas R. ; Bardo, Michael T. / Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats. In: Learning and Motivation. 2007 ; Vol. 38, No. 1. pp. 44-55.
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