Repeated immunolesions display diminished stress response signal

Zezong Gu, Juan Yu, Karin Werrbach-Perez, J. Regino Perez-Polo

    Research output: Contribution to journalArticle

    1 Scopus citations

    Abstract

    Cholinergic basal forebrain neurons (CBFNs) retrogradely transport neurotrophins released in the hippocampus and cortex as part of a general response to injury in a process that is impaired in the aged rodent and can be spared by the exogenous addition of pharmacological doses of nerve growth factor (NGF). This observation suggests that components of stress response signal transduction pathways in the aged CNS can be exogenously activated. The extent and mechanism of the endogenous stimulation of NGF in response to injury can be mimicked via treatment with 192 IgG-saporin of rat CNS, an immunolesion model. Here we report on the use of a conditioning lesion paradigm to determine if repeated partial immunolesions have a conditioning effect on the immunolesion-induced increases in NGF protein or decreases in choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activity.We report that chronic repeated immunolesions, as used here, were not as effective as a one time equivalent immunolesion in terms of induced NGF protein increases or decreasing ChAT and AChE activity in the hippocampus and cortex. Thus, chronic lesions resulting in cholinergic impairment typical of the aged CNS may differ from acute toxic models as a result of desensitization due to a conditioning effect of chronic subthreshold lesioning events in the CNS. Copyright (C) 2000 ISDN.

    Original languageEnglish (US)
    Pages (from-to)177-183
    Number of pages7
    JournalInternational Journal of Developmental Neuroscience
    Volume18
    Issue number2-3
    DOIs
    StatePublished - Jun 1 2000

    Keywords

    • 192 IgG-saporin
    • Acetylcholinesterase
    • Choline acetyltransferase
    • Cholinergic basal forebrain neuron
    • Conditioning
    • Immunolesion
    • Nerve growth factor

    ASJC Scopus subject areas

    • Developmental Neuroscience
    • Developmental Biology

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