Replication of Colorado tick fever virus within human hematopoietic progenitor cells

C. S. Philipp; C. Callaway; M. C. Chu; Hui Huang Gou Hui Huang; T. P. Monath; D. Trent; B. L. Evatt

doi:10.1128/jvi.67.4.2389-2395.1993

Replication of Colorado tick fever virus within human hematopoietic progenitor cells

C. S. Philipp, C. Callaway, M. C. Chu, Hui Huang Gou Hui Huang, T. P. Monath, D. Trent, B. L. Evatt

Research output: Contribution to journal › Comment/debate › peer-review

20 Scopus citations

Abstract

Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34⁺ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.

Original language	English (US)
Pages (from-to)	2389-2395
Number of pages	7
Journal	Journal of virology
Volume	67
Issue number	4
DOIs	https://doi.org/10.1128/jvi.67.4.2389-2395.1993
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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10.1128/jvi.67.4.2389-2395.1993

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title = "Replication of Colorado tick fever virus within human hematopoietic progenitor cells",

abstract = "Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.",

author = "Philipp, {C. S.} and C. Callaway and Chu, {M. C.} and {Gou Hui Huang}, {Hui Huang} and Monath, {T. P.} and D. Trent and Evatt, {B. L.}",

year = "1993",

doi = "10.1128/jvi.67.4.2389-2395.1993",

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T1 - Replication of Colorado tick fever virus within human hematopoietic progenitor cells

AU - Philipp, C. S.

AU - Callaway, C.

AU - Chu, M. C.

AU - Gou Hui Huang, Hui Huang

AU - Monath, T. P.

AU - Trent, D.

AU - Evatt, B. L.

PY - 1993

Y1 - 1993

N2 - Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.

AB - Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.

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U2 - 10.1128/jvi.67.4.2389-2395.1993

DO - 10.1128/jvi.67.4.2389-2395.1993

M3 - Comment/debate

C2 - 8445735

AN - SCOPUS:0027523236

VL - 67

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EP - 2395

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 4

ER -

Replication of Colorado tick fever virus within human hematopoietic progenitor cells

Abstract

ASJC Scopus subject areas

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