Replication of Colorado tick fever virus within human hematopoietic progenitor cells

Claire S. Philipp, Carey Callaway, May C. Chu, Guo Hui Huang, Thomas P. Monath, Dennis Trent, Bruce L. Evatt

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.

Original languageEnglish (US)
Pages (from-to)2389-2395
Number of pages7
JournalJournal of Virology
Volume67
Issue number4
StatePublished - Apr 1993

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ASJC Scopus subject areas

  • Immunology

Cite this

Philipp, C. S., Callaway, C., Chu, M. C., Huang, G. H., Monath, T. P., Trent, D., & Evatt, B. L. (1993). Replication of Colorado tick fever virus within human hematopoietic progenitor cells. Journal of Virology, 67(4), 2389-2395.