Replication of Colorado tick fever virus within human hematopoietic progenitor cells

C. S. Philipp, C. Callaway, M. C. Chu, Hui Huang Gou Hui Huang, T. P. Monath, D. Trent, B. L. Evatt

Research output: Contribution to journalComment/debate

16 Scopus citations

Abstract

Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.

Original languageEnglish (US)
Pages (from-to)2389-2395
Number of pages7
JournalJournal of virology
Volume67
Issue number4
DOIs
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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  • Cite this

    Philipp, C. S., Callaway, C., Chu, M. C., Gou Hui Huang, H. H., Monath, T. P., Trent, D., & Evatt, B. L. (1993). Replication of Colorado tick fever virus within human hematopoietic progenitor cells. Journal of virology, 67(4), 2389-2395. https://doi.org/10.1128/jvi.67.4.2389-2395.1993