Abstract
Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2389-2395 |
| Number of pages | 7 |
| Journal | Journal of Virology |
| Volume | 67 |
| Issue number | 4 |
| State | Published - Apr 1993 |
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ASJC Scopus subject areas
- Immunology
Cite this
Replication of Colorado tick fever virus within human hematopoietic progenitor cells. / Philipp, Claire S.; Callaway, Carey; Chu, May C.; Huang, Guo Hui; Monath, Thomas P.; Trent, Dennis; Evatt, Bruce L.
In: Journal of Virology, Vol. 67, No. 4, 04.1993, p. 2389-2395.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Replication of Colorado tick fever virus within human hematopoietic progenitor cells
AU - Philipp, Claire S.
AU - Callaway, Carey
AU - Chu, May C.
AU - Huang, Guo Hui
AU - Monath, Thomas P.
AU - Trent, Dennis
AU - Evatt, Bruce L.
PY - 1993/4
Y1 - 1993/4
N2 - Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.
AB - Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.
UR - http://www.scopus.com/inward/record.url?scp=0027523236&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027523236&partnerID=8YFLogxK
M3 - Article
VL - 67
SP - 2389
EP - 2395
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 4
ER -