Replication of Colorado tick fever virus within human hematopoietic progenitor cells

Claire S. Philipp, Carey Callaway, May C. Chu, Guo Hui Huang, Thomas P. Monath, Dennis Trent, Bruce L. Evatt

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Significant neutropenia, as well as thrombocytopenia and a mild anemia, occurs in patients infected with Colorado tick fever virus. In this study, human bone marrow CD34+ cells and KG-1a cells, a human hematopoietic progenitor cell line, were infected in vitro with Colorado tick fever virus. The time course and morphological appearance of viral replication in human progenitor cells were similar to those seen in erythroblasts and in HEL cells and suggest one possible mechanism for the clinical hematologic findings.

Original languageEnglish (US)
Pages (from-to)2389-2395
Number of pages7
JournalJournal of Virology
Volume67
Issue number4
StatePublished - Apr 1993

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Colorado tick fever virus
Hematopoietic Stem Cells
erythroblasts
Erythroblasts
neutropenia
thrombocytopenia
bone marrow cells
virus replication
Neutropenia
Bone Marrow Cells
Thrombocytopenia
anemia
stem cells
Anemia
Stem Cells
cell lines
cells
Cell Line
hematopoietic stem cells

ASJC Scopus subject areas

  • Immunology

Cite this

Philipp, C. S., Callaway, C., Chu, M. C., Huang, G. H., Monath, T. P., Trent, D., & Evatt, B. L. (1993). Replication of Colorado tick fever virus within human hematopoietic progenitor cells. Journal of Virology, 67(4), 2389-2395.

Replication of Colorado tick fever virus within human hematopoietic progenitor cells. / Philipp, Claire S.; Callaway, Carey; Chu, May C.; Huang, Guo Hui; Monath, Thomas P.; Trent, Dennis; Evatt, Bruce L.

In: Journal of Virology, Vol. 67, No. 4, 04.1993, p. 2389-2395.

Research output: Contribution to journalArticle

Philipp, CS, Callaway, C, Chu, MC, Huang, GH, Monath, TP, Trent, D & Evatt, BL 1993, 'Replication of Colorado tick fever virus within human hematopoietic progenitor cells', Journal of Virology, vol. 67, no. 4, pp. 2389-2395.
Philipp CS, Callaway C, Chu MC, Huang GH, Monath TP, Trent D et al. Replication of Colorado tick fever virus within human hematopoietic progenitor cells. Journal of Virology. 1993 Apr;67(4):2389-2395.
Philipp, Claire S. ; Callaway, Carey ; Chu, May C. ; Huang, Guo Hui ; Monath, Thomas P. ; Trent, Dennis ; Evatt, Bruce L. / Replication of Colorado tick fever virus within human hematopoietic progenitor cells. In: Journal of Virology. 1993 ; Vol. 67, No. 4. pp. 2389-2395.
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