Replication of hemorrhagic fever viruses in monocytic cells.

R. M. Lewis, J. C. Morrill, P. B. Jahrling, T. M. Cosgriff

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Monocytes play a central role in protection against many viruses. In some infections they are target cells for viral replication. There is increasing evidence that these cells may also be important in regulation of hemostasis. The part played by monocytic cells in the pathogenesis of hemorrhage in the viral hemorrhagic fevers is presently uncertain. Monocytes and monocytic cell lines have been used to investigate the ability of viruses to infect these cells in vitro. Several factors may affect the ability of a particular virus to infect monocytic cells, including specific antiserum to virus and the degree of cellular maturation. The effect of cellular maturation on the replication of Rift Valley fever virus in the U937 cell line is discussed in light of studies on the infectivity of other viruses for monocytic cells. Data supporting the ability of specific antibody to enhance the infectivity of Pichinde virus and Lassa fever virus for U937 cells are presented.

Original languageEnglish (US)
JournalReviews of Infectious Diseases
Volume11 Suppl 4
StatePublished - May 1989
Externally publishedYes

Fingerprint

Fever
Viruses
U937 Cells
Pichinde virus
Monocytes
Lassa Fever
Lassa virus
Viral Hemorrhagic Fevers
Rift Valley fever virus
Cell Line
Hemostasis
Immune Sera
Hemorrhage
Antibodies
Infection

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Lewis, R. M., Morrill, J. C., Jahrling, P. B., & Cosgriff, T. M. (1989). Replication of hemorrhagic fever viruses in monocytic cells. Reviews of Infectious Diseases, 11 Suppl 4.

Replication of hemorrhagic fever viruses in monocytic cells. / Lewis, R. M.; Morrill, J. C.; Jahrling, P. B.; Cosgriff, T. M.

In: Reviews of Infectious Diseases, Vol. 11 Suppl 4, 05.1989.

Research output: Contribution to journalArticle

Lewis, RM, Morrill, JC, Jahrling, PB & Cosgriff, TM 1989, 'Replication of hemorrhagic fever viruses in monocytic cells.', Reviews of Infectious Diseases, vol. 11 Suppl 4.
Lewis RM, Morrill JC, Jahrling PB, Cosgriff TM. Replication of hemorrhagic fever viruses in monocytic cells. Reviews of Infectious Diseases. 1989 May;11 Suppl 4.
Lewis, R. M. ; Morrill, J. C. ; Jahrling, P. B. ; Cosgriff, T. M. / Replication of hemorrhagic fever viruses in monocytic cells. In: Reviews of Infectious Diseases. 1989 ; Vol. 11 Suppl 4.
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