TY - JOUR
T1 - Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus Optical Coherence Tomography Measurements
AU - González-García, Alberto O.
AU - Vizzeri, Gianmarco
AU - Bowd, Christopher
AU - Medeiros, Felipe A.
AU - Zangwill, Linda M.
AU - Weinreb, Robert N.
N1 - Funding Information:
This study was supported by Grants EY011008 and EY008208 from the National Institutes of Health, Bethesda, Maryland. Dr Weinreb is a consultant for Carl Zeiss Meditec, Dublin, California. Drs Weinreb, Zangwill, and Medeiros receive research support from Carl Zeiss Meditec, Optovue Inc, Fremont, California, and Heidelberg Engineering, Dossenheim, Germany. Dr Medeiros also receives research support from Reichert Ophthalmic Instruments, Depew, New York. Dr Bowd receives research support from Lace Elettronica, Pisa, Italy. Involved in design of study (A.O.G.-G., G.V., C.B., L.M.Z., R.N.W.); conduct of study (A.O.G.-G., G.V.); data collection, management, and analysis (A.O.G.-G., G.V., C.B., L.M.Z.); and preparation, review, and approval of the manuscript (A.O.G.-G., G.V., C.B., L.M.Z., F.A.M., R.N.W.). The University of California San Diego Institutional Review Board approved all protocols and adheres to the Declaration of Helsinki. Health Insurance Portability and Accountability Act authorization forms were obtained from all participants.
PY - 2009/6
Y1 - 2009/6
N2 - Purpose: To evaluate RTVue spectral-domain optical coherence tomography (OCT) (Optovue Inc, Fremont, California, USA) reproducibility and to assess agreement with Stratus time-domain OCT (Carl Zeiss Meditec, Dublin, California, USA) measurements. Design: Observational clinical study. Methods: Scans were obtained from both eyes of all participants 3 times using the RTVue nerve head map 4-mm diameter protocol and once using Stratus OCT within the same session. RTVue reproducibility and agreement with Stratus OCT were evaluated for retinal nerve fiber layer (RNFL) and optic disc measurements. Results: Thirty healthy participants (60 eyes) and 38 glaucoma patients (76 eyes) were included in the study. RTVue reproducibility was good in both healthy participants and patients. For average RNFL thickness, the intraclass correlation coefficients in healthy eyes and patient eyes were 0.97 whereas for rim area they were 0.97 and 0.96, respectively. The correlation between RTVue and Stratus measurements generally was good, especially for average RNFL thickness (healthy eyes and patient eyes, r2 = 0.82 and 0.86, respectively) and rim volume (healthy eyes and patient eyes, r2 = 0.78 and 0.76, respectively). Bland-Altman plots showed good agreement between the instruments, with better agreement for average RNFL thickness (95% limits of agreement in healthy eyes and patient eyes, -8.6 to 12 μm and -5.6 to -14.8 μm, respectively) than optic disc parameters. Cup-to-disc ratio 95% limits of agreement in healthy eyes and patient eyes were -0.3 to 0.4 and -0.2 to 0.3, respectively. Optic disc measurements with RTVue were smaller than those with Stratus OCT (eg, disc area was on average 0.4 mm2 smaller and rim area was 0.3 mm2 smaller with RTVue). Conclusions: Reproducibility of RTVue RNFL and optic disc measurements was excellent in both groups. The level of agreement between RTVue and Stratus measurements suggests that RTVue has the potential to detect glaucomatous structural changes.
AB - Purpose: To evaluate RTVue spectral-domain optical coherence tomography (OCT) (Optovue Inc, Fremont, California, USA) reproducibility and to assess agreement with Stratus time-domain OCT (Carl Zeiss Meditec, Dublin, California, USA) measurements. Design: Observational clinical study. Methods: Scans were obtained from both eyes of all participants 3 times using the RTVue nerve head map 4-mm diameter protocol and once using Stratus OCT within the same session. RTVue reproducibility and agreement with Stratus OCT were evaluated for retinal nerve fiber layer (RNFL) and optic disc measurements. Results: Thirty healthy participants (60 eyes) and 38 glaucoma patients (76 eyes) were included in the study. RTVue reproducibility was good in both healthy participants and patients. For average RNFL thickness, the intraclass correlation coefficients in healthy eyes and patient eyes were 0.97 whereas for rim area they were 0.97 and 0.96, respectively. The correlation between RTVue and Stratus measurements generally was good, especially for average RNFL thickness (healthy eyes and patient eyes, r2 = 0.82 and 0.86, respectively) and rim volume (healthy eyes and patient eyes, r2 = 0.78 and 0.76, respectively). Bland-Altman plots showed good agreement between the instruments, with better agreement for average RNFL thickness (95% limits of agreement in healthy eyes and patient eyes, -8.6 to 12 μm and -5.6 to -14.8 μm, respectively) than optic disc parameters. Cup-to-disc ratio 95% limits of agreement in healthy eyes and patient eyes were -0.3 to 0.4 and -0.2 to 0.3, respectively. Optic disc measurements with RTVue were smaller than those with Stratus OCT (eg, disc area was on average 0.4 mm2 smaller and rim area was 0.3 mm2 smaller with RTVue). Conclusions: Reproducibility of RTVue RNFL and optic disc measurements was excellent in both groups. The level of agreement between RTVue and Stratus measurements suggests that RTVue has the potential to detect glaucomatous structural changes.
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U2 - 10.1016/j.ajo.2008.12.032
DO - 10.1016/j.ajo.2008.12.032
M3 - Article
C2 - 19268891
AN - SCOPUS:61549127372
SN - 0002-9394
VL - 147
SP - 1067-1074.e1
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 6
ER -