Reproducibility of the Heidelberg retina tomograph III glaucoma probability score

Giovanni Taibbi, Paolo Fogagnolo, Nicola Orzalesi, Luca Rossetti

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

PURPOSE: To evaluate the intrasession reproducibility of the Heidelberg Retina Tomograph III (HRT III) Glaucoma Probability Score (GPS) and analyze the factors that may affect it. PATIENTS AND METHODS: Twenty normal subjects and 20 glaucomatous patients underwent 10 HRT III examinations of 1 randomly selected eye during the same session. The reproducibility of the GPS and its parameters was assessed by calculating the intraclass correlation coefficients (ICCs) and 95% confidence intervals of the study population as a whole, and of the 2 subgroups. The factors influencing individual reproducibility were evaluated by means of regression analysis. RESULTS: The reproducibility of the GPS parameters (at a confidence level of 95%) was almost perfect in the population as a whole (ICCs 0.964-0.856) and in the normal subjects (ICCs 0.976-0.897), but decreased in the glaucoma patients in whom it ranged from almost perfect to substantial (ICCs 0.922-0.705). The parameters were mainly influenced by image quality, but also by diagnosis and age, although the probability of glaucoma did not seem to depend on these variables. CONCLUSIONS: GPS is a highly reproducible diagnostic tool, especially in the case of "good" or better quality images as evaluated by the HRT software; moreover, the reproducibility of the GPS parameters was significantly better in normal subjects than in glaucoma patients.

Original languageEnglish (US)
Pages (from-to)247-252
Number of pages6
JournalJournal of Glaucoma
Volume18
Issue number3
DOIs
StatePublished - Mar 2009
Externally publishedYes

Fingerprint

Glaucoma
Retina
Population
Statistical Factor Analysis
Software
Regression Analysis
Confidence Intervals

Keywords

  • Confocal scanning laser ophthalmoscope
  • Glaucoma
  • Glaucoma probability score
  • HRT
  • Reproducibility

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Reproducibility of the Heidelberg retina tomograph III glaucoma probability score. / Taibbi, Giovanni; Fogagnolo, Paolo; Orzalesi, Nicola; Rossetti, Luca.

In: Journal of Glaucoma, Vol. 18, No. 3, 03.2009, p. 247-252.

Research output: Contribution to journalArticle

Taibbi, Giovanni ; Fogagnolo, Paolo ; Orzalesi, Nicola ; Rossetti, Luca. / Reproducibility of the Heidelberg retina tomograph III glaucoma probability score. In: Journal of Glaucoma. 2009 ; Vol. 18, No. 3. pp. 247-252.
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N2 - PURPOSE: To evaluate the intrasession reproducibility of the Heidelberg Retina Tomograph III (HRT III) Glaucoma Probability Score (GPS) and analyze the factors that may affect it. PATIENTS AND METHODS: Twenty normal subjects and 20 glaucomatous patients underwent 10 HRT III examinations of 1 randomly selected eye during the same session. The reproducibility of the GPS and its parameters was assessed by calculating the intraclass correlation coefficients (ICCs) and 95% confidence intervals of the study population as a whole, and of the 2 subgroups. The factors influencing individual reproducibility were evaluated by means of regression analysis. RESULTS: The reproducibility of the GPS parameters (at a confidence level of 95%) was almost perfect in the population as a whole (ICCs 0.964-0.856) and in the normal subjects (ICCs 0.976-0.897), but decreased in the glaucoma patients in whom it ranged from almost perfect to substantial (ICCs 0.922-0.705). The parameters were mainly influenced by image quality, but also by diagnosis and age, although the probability of glaucoma did not seem to depend on these variables. CONCLUSIONS: GPS is a highly reproducible diagnostic tool, especially in the case of "good" or better quality images as evaluated by the HRT software; moreover, the reproducibility of the GPS parameters was significantly better in normal subjects than in glaucoma patients.

AB - PURPOSE: To evaluate the intrasession reproducibility of the Heidelberg Retina Tomograph III (HRT III) Glaucoma Probability Score (GPS) and analyze the factors that may affect it. PATIENTS AND METHODS: Twenty normal subjects and 20 glaucomatous patients underwent 10 HRT III examinations of 1 randomly selected eye during the same session. The reproducibility of the GPS and its parameters was assessed by calculating the intraclass correlation coefficients (ICCs) and 95% confidence intervals of the study population as a whole, and of the 2 subgroups. The factors influencing individual reproducibility were evaluated by means of regression analysis. RESULTS: The reproducibility of the GPS parameters (at a confidence level of 95%) was almost perfect in the population as a whole (ICCs 0.964-0.856) and in the normal subjects (ICCs 0.976-0.897), but decreased in the glaucoma patients in whom it ranged from almost perfect to substantial (ICCs 0.922-0.705). The parameters were mainly influenced by image quality, but also by diagnosis and age, although the probability of glaucoma did not seem to depend on these variables. CONCLUSIONS: GPS is a highly reproducible diagnostic tool, especially in the case of "good" or better quality images as evaluated by the HRT software; moreover, the reproducibility of the GPS parameters was significantly better in normal subjects than in glaucoma patients.

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