Repurposing quinacrine against Ebola virus infection in vivo

Thomas R. Lane, Jason E. Comer, Alexander Freiberg, Peter B. Madrid, Sean Ekins

Research output: Contribution to journalArticle

Abstract

Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar) in vitro inhibitor. In the current study, quinacrine 25 mg/kg was shown to protect 70% of mice (statistically significant) from a lethal challenge with mouse-adapted EBOV with once-daily intraperitoneal dosing for 8 days.

Original languageEnglish (US)
Article numbere01142-19
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number9
DOIs
StatePublished - Jan 1 2019

Fingerprint

Ebola Hemorrhagic Fever
Quinacrine
Ebolavirus
Antimalarials
Pharmaceutical Preparations

Keywords

  • Antiviral
  • Ebola virus
  • Ebola virus disease
  • Quinacrine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Repurposing quinacrine against Ebola virus infection in vivo. / Lane, Thomas R.; Comer, Jason E.; Freiberg, Alexander; Madrid, Peter B.; Ekins, Sean.

In: Antimicrobial Agents and Chemotherapy, Vol. 63, No. 9, e01142-19, 01.01.2019.

Research output: Contribution to journalArticle

Lane, Thomas R. ; Comer, Jason E. ; Freiberg, Alexander ; Madrid, Peter B. ; Ekins, Sean. / Repurposing quinacrine against Ebola virus infection in vivo. In: Antimicrobial Agents and Chemotherapy. 2019 ; Vol. 63, No. 9.
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