Repurposing quinacrine against Ebola virus infection in vivo

Thomas R. Lane, Jason E. Comer, Alexander N. Freiberg, Peter B. Madrid, Sean Ekins

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar) in vitro inhibitor. In the current study, quinacrine 25 mg/kg was shown to protect 70% of mice (statistically significant) from a lethal challenge with mouse-adapted EBOV with once-daily intraperitoneal dosing for 8 days.

Original languageEnglish (US)
Article numbere01142-19
JournalAntimicrobial agents and chemotherapy
Volume63
Issue number9
DOIs
StatePublished - 2019

Keywords

  • Antiviral
  • Ebola virus
  • Ebola virus disease
  • Quinacrine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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