Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long after the Resolution of the Infection

Veronica Bordoni; Eleonora Lalle; Francesca Colavita; Andrea Baiocchini; Roberta Nardacci; Laura Falasca; Fabrizio Carletti; Eleonora Cimini; Licia Bordi; Gary Kobinger; Valentina D'Ambrosio; Fabio Natale; Antonella Giancotti; Lucia Manganaro; Franca Del Nonno; Alimuddin Zumla; Giuseppina Liuzzi; Giuseppe Ippolito; Maria Rosaria Capobianchi; Chiara Agrati; Concetta Castilletti

doi:10.1093/ofid/ofz342

Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long after the Resolution of the Infection

Veronica Bordoni, Eleonora Lalle, Francesca Colavita, Andrea Baiocchini, Roberta Nardacci, Laura Falasca, Fabrizio Carletti, Eleonora Cimini, Licia Bordi, Gary Kobinger, Valentina D'Ambrosio, Fabio Natale, Antonella Giancotti, Lucia Manganaro, Franca Del Nonno, Alimuddin Zumla, Giuseppina Liuzzi, Giuseppe Ippolito, Maria Rosaria Capobianchi, Chiara AgratiConcetta Castilletti

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.

Original language	English (US)
Article number	ofz342
Journal	Open Forum Infectious Diseases
Volume	6
Issue number	10
DOIs	https://doi.org/10.1093/ofid/ofz342
State	Published - Oct 1 2019
Externally published	Yes

Keywords

Zika virus
mesenchymal cells
placenta
vertical transmission
viral reservoir

ASJC Scopus subject areas

Oncology
Infectious Diseases

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10.1093/ofid/ofz342

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Bordoni, V., Lalle, E., Colavita, F., Baiocchini, A., Nardacci, R., Falasca, L., Carletti, F., Cimini, E., Bordi, L., Kobinger, G., D'Ambrosio, V., Natale, F., Giancotti, A., Manganaro, L., Del Nonno, F., Zumla, A., Liuzzi, G., Ippolito, G., Capobianchi, M. R., ... Castilletti, C. (2019). Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long after the Resolution of the Infection. Open Forum Infectious Diseases, 6(10), Article ofz342. https://doi.org/10.1093/ofid/ofz342

Bordoni, V, Lalle, E, Colavita, F, Baiocchini, A, Nardacci, R, Falasca, L, Carletti, F, Cimini, E, Bordi, L, Kobinger, G, D'Ambrosio, V, Natale, F, Giancotti, A, Manganaro, L, Del Nonno, F, Zumla, A, Liuzzi, G, Ippolito, G, Capobianchi, MR, Agrati, C & Castilletti, C 2019, 'Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long after the Resolution of the Infection', Open Forum Infectious Diseases, vol. 6, no. 10, ofz342. https://doi.org/10.1093/ofid/ofz342

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title = "Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long after the Resolution of the Infection",

abstract = "The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.",

keywords = "Zika virus, mesenchymal cells, placenta, vertical transmission, viral reservoir",

author = "Veronica Bordoni and Eleonora Lalle and Francesca Colavita and Andrea Baiocchini and Roberta Nardacci and Laura Falasca and Fabrizio Carletti and Eleonora Cimini and Licia Bordi and Gary Kobinger and Valentina D'Ambrosio and Fabio Natale and Antonella Giancotti and Lucia Manganaro and {Del Nonno}, Franca and Alimuddin Zumla and Giuseppina Liuzzi and Giuseppe Ippolito and Capobianchi, {Maria Rosaria} and Chiara Agrati and Concetta Castilletti",

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AU - Bordoni, Veronica

AU - Lalle, Eleonora

AU - Colavita, Francesca

AU - Baiocchini, Andrea

AU - Nardacci, Roberta

AU - Falasca, Laura

AU - Carletti, Fabrizio

AU - Cimini, Eleonora

AU - Bordi, Licia

AU - Kobinger, Gary

AU - D'Ambrosio, Valentina

AU - Natale, Fabio

AU - Giancotti, Antonella

AU - Manganaro, Lucia

AU - Del Nonno, Franca

AU - Zumla, Alimuddin

AU - Liuzzi, Giuseppina

AU - Ippolito, Giuseppe

AU - Capobianchi, Maria Rosaria

AU - Agrati, Chiara

AU - Castilletti, Concetta

PY - 2019/10/1

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AB - The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.

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KW - mesenchymal cells

KW - placenta

KW - vertical transmission

KW - viral reservoir

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Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long after the Resolution of the Infection

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Keywords

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