@article{0210bb33f17543a09afb79802fb97ea8,
title = "Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long after the Resolution of the Infection",
abstract = "The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.",
keywords = "Zika virus, mesenchymal cells, placenta, vertical transmission, viral reservoir",
author = "Veronica Bordoni and Eleonora Lalle and Francesca Colavita and Andrea Baiocchini and Roberta Nardacci and Laura Falasca and Fabrizio Carletti and Eleonora Cimini and Licia Bordi and Gary Kobinger and Valentina D'Ambrosio and Fabio Natale and Antonella Giancotti and Lucia Manganaro and {Del Nonno}, Franca and Alimuddin Zumla and Giuseppina Liuzzi and Giuseppe Ippolito and Capobianchi, {Maria Rosaria} and Chiara Agrati and Concetta Castilletti",
note = "Funding Information: Financial support. This study was supported by funds from the Italian Ministry of Health (Ricerca Corrente, line 1, RF-2016-02364155 and GR-2016-02362110) and from the European Union{\textquoteright}s Horizon 2020 Research and Innovation Programme European Virus Archive (EVAg, 653316). Funding Information: Giuseppe Ippolito and Alimuddin Zumla are members of the PANDORA-ID-NET Consortium, which is funded by the European and Developing Countries Clinical Trials Partnership (EDCTP2) programme (EDCTP Reg/Grant RIA2016E-1609), which is supported under Horizon 2020. Gary Kobinger, Alimuddin Zumla, and Giuseppe Ippolito are members of the International Public Health Crisis Group (IPHCG). Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",
year = "2019",
month = oct,
day = "1",
doi = "10.1093/ofid/ofz342",
language = "English (US)",
volume = "6",
journal = "Open Forum Infectious Diseases",
issn = "2328-8957",
publisher = "Oxford University Press",
number = "10",
}