Research Design, Organization, and Sample Characteristics of the Maternal PKU Collaborative Study

Richard Koch, Colleen Azen, Eva Friedman, William Hanley, Harvey Levy, Reuben Matalon, Bobbye Rouse, Friedrich Trefz, Jiaping Ning, Felix De La Cruz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective. The Maternal PKU Collaborative Study (MPKUCS) was initiated in 1984 by the National Institute of Child Health and Human Development (NICHD). The purpose was to assess the efficacy of dietary restriction of phenylalanine in reducing morbidity in offspring of women with hyperphenylalaninemia (HPA). A contract was awarded to Childrens Hospital Los Angeles as the Coordinating Center to provide implementation of the research protocol, data collection, and analysis. Methods. The Study included four regional contributing centers: Childrens Hospital Los Angeles (Western Region), Boston Children's Hospital (Northeast Region), University of Illinois (Midwest Region), and University of Texas Medical Branch, Galveston (Southeast Region). Within each region, many participating clinics were responsible for obstetric care, treatment, and monitoring protocols. In 1985, Canada joined the MPKUCS, and in 1992, Germany entered. They were selected because they provided dietary supplies and strong professional services. Acquisition began in 1984 and ended in October 1995. The study included 574 pregnancies in women with HPA and 100 control subjects matched on age, race, parity, and weeks of gestation. The sample included women with blood phenylalanine values >240 μmol/L, 66% of whom had classical PKU, 22% had atypical PKU, and 12% had mild HPA. Informed consents were obtained on all participants. The women ranged in age from 15 to 36 years of age, with a mean age at conception of 23 years. Teenage pregnancies accounted for 19%. Seventy-five percent graduated from high school. Offspring included 416 newborns, 317 of whom were evaluated at 4 years of age and 289 at 6 to 7 years. Follow-up involved medical, nutritional, psychosocial, and psychological assessments. Conclusion. Women with PKU treated before conception and in control of their blood phenylalanine levels between 120 and 360 μmol/L (2-6 mg) exhibited normal pregnancies and neonatal outcome. Surprisingly, women who achieved control in the recommended range by 8 weeks of pregnancy also had a normal fetal outcome.

Original languageEnglish (US)
Pages (from-to)1519-1522
Number of pages4
JournalPediatrics
Volume112
Issue number6 II
StatePublished - Dec 2003

Fingerprint

Maternal Phenylketonuria
Phenylketonurias
Research Design
Organizations
Phenylalanine
Los Angeles
Pregnancy
National Institute of Child Health and Human Development (U.S.)
Pregnancy in Adolescence
Pregnancy Outcome
Clinical Protocols
Contracts
Parity
Informed Consent
Obstetrics
Canada
Germany
Newborn Infant
Psychology
Morbidity

Keywords

  • Hyperphenylalaninemic
  • Maternal PKU Collaborative Study
  • Phenylalanine
  • Phenylalanine-restricted diet

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Koch, R., Azen, C., Friedman, E., Hanley, W., Levy, H., Matalon, R., ... De La Cruz, F. (2003). Research Design, Organization, and Sample Characteristics of the Maternal PKU Collaborative Study. Pediatrics, 112(6 II), 1519-1522.

Research Design, Organization, and Sample Characteristics of the Maternal PKU Collaborative Study. / Koch, Richard; Azen, Colleen; Friedman, Eva; Hanley, William; Levy, Harvey; Matalon, Reuben; Rouse, Bobbye; Trefz, Friedrich; Ning, Jiaping; De La Cruz, Felix.

In: Pediatrics, Vol. 112, No. 6 II, 12.2003, p. 1519-1522.

Research output: Contribution to journalArticle

Koch, R, Azen, C, Friedman, E, Hanley, W, Levy, H, Matalon, R, Rouse, B, Trefz, F, Ning, J & De La Cruz, F 2003, 'Research Design, Organization, and Sample Characteristics of the Maternal PKU Collaborative Study', Pediatrics, vol. 112, no. 6 II, pp. 1519-1522.
Koch R, Azen C, Friedman E, Hanley W, Levy H, Matalon R et al. Research Design, Organization, and Sample Characteristics of the Maternal PKU Collaborative Study. Pediatrics. 2003 Dec;112(6 II):1519-1522.
Koch, Richard ; Azen, Colleen ; Friedman, Eva ; Hanley, William ; Levy, Harvey ; Matalon, Reuben ; Rouse, Bobbye ; Trefz, Friedrich ; Ning, Jiaping ; De La Cruz, Felix. / Research Design, Organization, and Sample Characteristics of the Maternal PKU Collaborative Study. In: Pediatrics. 2003 ; Vol. 112, No. 6 II. pp. 1519-1522.
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abstract = "Objective. The Maternal PKU Collaborative Study (MPKUCS) was initiated in 1984 by the National Institute of Child Health and Human Development (NICHD). The purpose was to assess the efficacy of dietary restriction of phenylalanine in reducing morbidity in offspring of women with hyperphenylalaninemia (HPA). A contract was awarded to Childrens Hospital Los Angeles as the Coordinating Center to provide implementation of the research protocol, data collection, and analysis. Methods. The Study included four regional contributing centers: Childrens Hospital Los Angeles (Western Region), Boston Children's Hospital (Northeast Region), University of Illinois (Midwest Region), and University of Texas Medical Branch, Galveston (Southeast Region). Within each region, many participating clinics were responsible for obstetric care, treatment, and monitoring protocols. In 1985, Canada joined the MPKUCS, and in 1992, Germany entered. They were selected because they provided dietary supplies and strong professional services. Acquisition began in 1984 and ended in October 1995. The study included 574 pregnancies in women with HPA and 100 control subjects matched on age, race, parity, and weeks of gestation. The sample included women with blood phenylalanine values >240 μmol/L, 66{\%} of whom had classical PKU, 22{\%} had atypical PKU, and 12{\%} had mild HPA. Informed consents were obtained on all participants. The women ranged in age from 15 to 36 years of age, with a mean age at conception of 23 years. Teenage pregnancies accounted for 19{\%}. Seventy-five percent graduated from high school. Offspring included 416 newborns, 317 of whom were evaluated at 4 years of age and 289 at 6 to 7 years. Follow-up involved medical, nutritional, psychosocial, and psychological assessments. Conclusion. Women with PKU treated before conception and in control of their blood phenylalanine levels between 120 and 360 μmol/L (2-6 mg) exhibited normal pregnancies and neonatal outcome. Surprisingly, women who achieved control in the recommended range by 8 weeks of pregnancy also had a normal fetal outcome.",
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