Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease

H. Rheinallt Parri, Caterina M. Hernandez, Kelly T. Dineley

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery that Aβ is bound to α7 nAChRs under many experimental settings, including post-mortem AD brain, much effort has been expended to understand the implications of this interaction in the disease milieu. This research update will review the current literature on the α7 nAChR-Aβ interaction in vitro and in vivo, the functional consequences of this interaction from sub-cellular to cognitive levels, and discuss the implications these relationships might have for AD therapies.

Original languageEnglish (US)
Pages (from-to)931-942
Number of pages12
JournalBiochemical Pharmacology
Volume82
Issue number8
DOIs
StatePublished - Oct 15 2011

Keywords

  • Alzheimer's disease
  • Amyloid
  • Cholinergic
  • Neuroprotection
  • Oligomer
  • Review

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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