Resiniferatoxin reversibly blocks adjuvant-induced thermal hyperalgesia in the rat

Yi Hong Zhang, Yong Chen, Zhi Qi Zhao

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The role of capsaicin-sensitive sensory afferents and mast cells in complete Freund's adjuvant (CFA)-induced thermal hyperalgesia and edema was investigated in rats. A single systemic injection of resiniferatoxin produced a reversible prevention of adjuvant-induced thermal hyperalgesia which lasted several days. In addition, resiniferatoxin markedly reduced the early edema. Chronic degranulation of mast cells with compound 48/80 also reduced the thermal hyperalgesia and edema, especially in the early phase of inflammation. Co-pretreatment with resiniferatoxin and compound 48/80 induced effects similar to those of resiniferatoxin alone. The data support the involvement of capsaicin-sensitive fibers in the adjuvant-induced inflammation.

Original languageEnglish (US)
Pages (from-to)301-304
Number of pages4
JournalEuropean Journal of Pharmacology
Volume481
Issue number2-3
DOIs
StatePublished - Nov 28 2003

Keywords

  • Inflammation
  • Mast cell
  • Paw edema
  • Resiniferatoxin
  • Thermal hyperalgesia

ASJC Scopus subject areas

  • Pharmacology

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