Resiniferatoxin reversibly blocks adjuvant-induced thermal hyperalgesia in the rat

Yi Hong Zhang, Yong Chen, Zhi Qi Zhao

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The role of capsaicin-sensitive sensory afferents and mast cells in complete Freund's adjuvant (CFA)-induced thermal hyperalgesia and edema was investigated in rats. A single systemic injection of resiniferatoxin produced a reversible prevention of adjuvant-induced thermal hyperalgesia which lasted several days. In addition, resiniferatoxin markedly reduced the early edema. Chronic degranulation of mast cells with compound 48/80 also reduced the thermal hyperalgesia and edema, especially in the early phase of inflammation. Co-pretreatment with resiniferatoxin and compound 48/80 induced effects similar to those of resiniferatoxin alone. The data support the involvement of capsaicin-sensitive fibers in the adjuvant-induced inflammation.

Original languageEnglish (US)
Pages (from-to)301-304
Number of pages4
JournalEuropean Journal of Pharmacology
Volume481
Issue number2-3
DOIs
StatePublished - Nov 28 2003
Externally publishedYes

Fingerprint

Hyperalgesia
p-Methoxy-N-methylphenethylamine
Edema
Capsaicin
Mast Cells
Inflammation
Freund's Adjuvant
Injections
resiniferatoxin

Keywords

  • Inflammation
  • Mast cell
  • Paw edema
  • Resiniferatoxin
  • Thermal hyperalgesia

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Resiniferatoxin reversibly blocks adjuvant-induced thermal hyperalgesia in the rat. / Zhang, Yi Hong; Chen, Yong; Zhao, Zhi Qi.

In: European Journal of Pharmacology, Vol. 481, No. 2-3, 28.11.2003, p. 301-304.

Research output: Contribution to journalArticle

Zhang, Yi Hong ; Chen, Yong ; Zhao, Zhi Qi. / Resiniferatoxin reversibly blocks adjuvant-induced thermal hyperalgesia in the rat. In: European Journal of Pharmacology. 2003 ; Vol. 481, No. 2-3. pp. 301-304.
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