Resistance exercise prevents sarcopenia during bed rest unloading

Marcas M. Bamman, Mark S F Clarke, Daniel L. Feeback, Steven Lieberman, Bruce R. Stevens, Michael C. Greenisen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Bed rest unloading (BRU) is associated with sarcopenia (i.e. reduced muscle mass and strength) in load-bearing muscles We tested the hypothesis that increased mechanical load via resistance exercise would counteract BRU-induced sarcopenia in knee extensor muscles Sixteen healthy men (30±7 yr. 178±5 cm. 75±14 kg) completed 14 d of strict BRU Subjects were randomly assigned to no exercise (NOE, n=8) or knee extensor resistance exercise (REX, n=8). REX completed 5 sets to volitional fatigue (7-9 repetitions) on a horizontal leg press every other day. One-repetition maximum (1RM) strength was tested before BRU and on d 14. Muscle samples were removed from m. vastus lateralis by percutaneous needle biopsy before BRU and on d 14 and analyzed for type I and type II myofiber cross-sectional areas following metachromatic dye-AT Paso staining Data were analyzed by 2×2 ANOVA. Atrophy was found in type I (3952±538 to 3373±300 um2) and type II (4334±630 to 3581±459 um2) myofibers in NOE (p<0.05). REX maintained myofiber size m type I (4189±324 to 4094±444 um2) and type II (4027±353 to 4356±407 um2) myofibers 1RM was reduced (p<0.05) in NOE (229±7 to 208±8 kg) but did not change in REX (208±11 to 209±10 kg). These results indicate that sarcopenia during unloading can be prevented by a relatively low volume of resistance exercise.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

sarcopenia
Sarcopenia
strength training
Bed Rest
Unloading
Exercise
muscles
Muscle
knees
Muscles
mechanical loads
Knee
Bearings (structural)
atrophy
Quadriceps Muscle
dyes
Weight-Bearing
Muscle Strength
Needle Biopsy
biopsy

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Bamman, M. M., Clarke, M. S. F., Feeback, D. L., Lieberman, S., Stevens, B. R., & Greenisen, M. C. (1997). Resistance exercise prevents sarcopenia during bed rest unloading. FASEB Journal, 11(3).

Resistance exercise prevents sarcopenia during bed rest unloading. / Bamman, Marcas M.; Clarke, Mark S F; Feeback, Daniel L.; Lieberman, Steven; Stevens, Bruce R.; Greenisen, Michael C.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Bamman, MM, Clarke, MSF, Feeback, DL, Lieberman, S, Stevens, BR & Greenisen, MC 1997, 'Resistance exercise prevents sarcopenia during bed rest unloading', FASEB Journal, vol. 11, no. 3.
Bamman MM, Clarke MSF, Feeback DL, Lieberman S, Stevens BR, Greenisen MC. Resistance exercise prevents sarcopenia during bed rest unloading. FASEB Journal. 1997;11(3).
Bamman, Marcas M. ; Clarke, Mark S F ; Feeback, Daniel L. ; Lieberman, Steven ; Stevens, Bruce R. ; Greenisen, Michael C. / Resistance exercise prevents sarcopenia during bed rest unloading. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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