Resistin: An inflammatory cytokine. Role in cardiovascular diseases, diabetes and the metabolic syndrome

Nicola Abate, Hanaa S. Sallam, Manfredi Rizzo, Dragana Nikolic, Milan Obradovic, Predrag Bjelogrlic, Esma R. Isenovic

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Resistin is an adipocyte- and monocyte-derived cytokine which has been implicated in the modulation of insulin action, energy, glucose and lipid homeostasis. Resistin has been associated with insulin resistance and many of its known complications. As a molecular link between metabolic signals, inflammation, and vascular dysfunction, resistin can be proposed as playing a significant role in the heightened inflammatory state induced by metabolic stress linked to excessive caloric intake, thus contributing to the risk for metabolic syndrome (MetS), type 2 diabetes (T2DM), and cardiovascular diseases (CVD). In this review, we highlighted the role of resistin, as an inflammatory cytokine, in the development of CVD, T2DM and the MetS.

Original languageEnglish (US)
Pages (from-to)4961-4969
Number of pages9
JournalCurrent Pharmaceutical Design
Volume20
Issue number31
DOIs
StatePublished - Jan 1 2014

Keywords

  • Cardiovascular diseases
  • Metabolic syndrome
  • Resistin
  • Type 2 diabetes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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