Resistin

An inflammatory cytokine. Role in cardiovascular diseases, diabetes and the metabolic syndrome

Nicola Abate, Hanaa Sallam, Manfredi Rizzo, Dragana Nikolic, Milan Obradovic, Predrag Bjelogrlic, Esma R. Isenovic

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Resistin is an adipocyte- and monocyte-derived cytokine which has been implicated in the modulation of insulin action, energy, glucose and lipid homeostasis. Resistin has been associated with insulin resistance and many of its known complications. As a molecular link between metabolic signals, inflammation, and vascular dysfunction, resistin can be proposed as playing a significant role in the heightened inflammatory state induced by metabolic stress linked to excessive caloric intake, thus contributing to the risk for metabolic syndrome (MetS), type 2 diabetes (T2DM), and cardiovascular diseases (CVD). In this review, we highlighted the role of resistin, as an inflammatory cytokine, in the development of CVD, T2DM and the MetS.

Original languageEnglish (US)
Pages (from-to)4961-4969
Number of pages9
JournalCurrent Pharmaceutical Design
Volume20
Issue number31
DOIs
StatePublished - 2014

Fingerprint

Resistin
Cardiovascular Diseases
Cytokines
Physiological Stress
Energy Intake
Adipocytes
Type 2 Diabetes Mellitus
Blood Vessels
Insulin Resistance
Monocytes
Homeostasis
Insulin
Inflammation
Lipids
Glucose

Keywords

  • Cardiovascular diseases
  • Metabolic syndrome
  • Resistin
  • Type 2 diabetes

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Resistin : An inflammatory cytokine. Role in cardiovascular diseases, diabetes and the metabolic syndrome. / Abate, Nicola; Sallam, Hanaa; Rizzo, Manfredi; Nikolic, Dragana; Obradovic, Milan; Bjelogrlic, Predrag; Isenovic, Esma R.

In: Current Pharmaceutical Design, Vol. 20, No. 31, 2014, p. 4961-4969.

Research output: Contribution to journalArticle

Abate, Nicola ; Sallam, Hanaa ; Rizzo, Manfredi ; Nikolic, Dragana ; Obradovic, Milan ; Bjelogrlic, Predrag ; Isenovic, Esma R. / Resistin : An inflammatory cytokine. Role in cardiovascular diseases, diabetes and the metabolic syndrome. In: Current Pharmaceutical Design. 2014 ; Vol. 20, No. 31. pp. 4961-4969.
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