Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells

Tadahito Saito, Ronald W. Deskin, Antonella Casola, Helene Häeberle, Barbara Olszewska, Peter B. Ernst, Rafeul Alam, Pearay L. Ogra, Roberto Garofalo

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The presence of histamine and eosinophil cationic protein in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV)- induced bronchiolitis implies the activation of basophil and eosinophil leukocytes, but the specific mechanism of their recruitment has not been elucidated. Chemokines are potent and selective leukocyte chemotactic molecules that are also expressed by airway epithelial cells. Therefore, the pattern of chemokines produced in response to RSV infection was investigated in primary cultures of human nose- and adenoid-derived epithelial cells. Interleukin-8, growth-related peptide-α, and monocyte chemotactic protein-1 were constitutively released by uninfected epithelial cells and were not further enhanced by infection with RSV. RANTES (regulated upon activation, normal T cell-expressed and -secreted), which was present in negligible concentrations in uninfected cultures, was strongly induced by RSV infection, in a dose- and time-dependent manner. Through the release of RANTES, epithelial cells may control the selective concentration and activation of basophils and eosinophils in RSV-infected airway mucosa.

Original languageEnglish (US)
Pages (from-to)497-504
Number of pages8
JournalJournal of Infectious Diseases
Volume175
Issue number3
StatePublished - 1997

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Respiratory Syncytial Viruses
Chemokines
Respiratory Syncytial Virus Infections
Epithelial Cells
T-Lymphocytes
Basophils
Eosinophils
Leukocytes
Eosinophil Cationic Protein
Adenoids
Bronchiolitis
Chemokine CCL2
Interleukin-8
Nose
Histamine
Mucous Membrane
Peptides
Growth

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells. / Saito, Tadahito; Deskin, Ronald W.; Casola, Antonella; Häeberle, Helene; Olszewska, Barbara; Ernst, Peter B.; Alam, Rafeul; Ogra, Pearay L.; Garofalo, Roberto.

In: Journal of Infectious Diseases, Vol. 175, No. 3, 1997, p. 497-504.

Research output: Contribution to journalArticle

Saito, T, Deskin, RW, Casola, A, Häeberle, H, Olszewska, B, Ernst, PB, Alam, R, Ogra, PL & Garofalo, R 1997, 'Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells', Journal of Infectious Diseases, vol. 175, no. 3, pp. 497-504.
Saito, Tadahito ; Deskin, Ronald W. ; Casola, Antonella ; Häeberle, Helene ; Olszewska, Barbara ; Ernst, Peter B. ; Alam, Rafeul ; Ogra, Pearay L. ; Garofalo, Roberto. / Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells. In: Journal of Infectious Diseases. 1997 ; Vol. 175, No. 3. pp. 497-504.
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AU - Alam, Rafeul

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AB - The presence of histamine and eosinophil cationic protein in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV)- induced bronchiolitis implies the activation of basophil and eosinophil leukocytes, but the specific mechanism of their recruitment has not been elucidated. Chemokines are potent and selective leukocyte chemotactic molecules that are also expressed by airway epithelial cells. Therefore, the pattern of chemokines produced in response to RSV infection was investigated in primary cultures of human nose- and adenoid-derived epithelial cells. Interleukin-8, growth-related peptide-α, and monocyte chemotactic protein-1 were constitutively released by uninfected epithelial cells and were not further enhanced by infection with RSV. RANTES (regulated upon activation, normal T cell-expressed and -secreted), which was present in negligible concentrations in uninfected cultures, was strongly induced by RSV infection, in a dose- and time-dependent manner. Through the release of RANTES, epithelial cells may control the selective concentration and activation of basophils and eosinophils in RSV-infected airway mucosa.

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