Response of cerebral blood flow to changes in carbon dioxide tension during hypothermic cardiopulmonary bypass

Donald Prough, D. A. Stump, R. C. Roy, G. P. Gravlee, T. Williams, S. A. Mills, L. Hinshelwood, G. Howard

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Changes in cerebral blood flow (CBF) in response to changes in Pa(CO2) were measured by intraaortic injection of 133Xe in 12 patients during hypothermic (23-30° C) cardiopulmonary bypass. In each patient, CBF was determined at two randomly ordered levels of Pa(CO2) obtained by varying the rate of gas inflow into the pump oxygenator (Group I, n = 6) or by varying the percentage of CO2 added to the gas inflow (Group II, n = 6). Nasopharyngeal temperature, mean arterial pressure, pump-oxygenator flow, and hematocrit were maintained within a narrow range. In group I, a Pa(CO2) (uncorrected for body temperature) of 36 ± 4 mmHg (mean ± SD) was associated with a CBF of 13 ± 5 ml·100 g-1·min-1, while a Pa(CO2) of 42 ± 4 mmHg was associated with a CBF of 19 ± 10 ml·100 g-1·min-1. In group II, a Pa(CO2) of 47 ± 3 mmHg was associated with a CBF of 20 ± 8 ml·100 g-1·min-1, and a Pa(CO2) of 53 ± 3 mmHg was associated with a CBF of 26 ± 9 ml·100 g-1·min-1. Within group I, the difference in CBF was significant (P < 0.05); within group II, the difference in CBF was significant at the P < 0.002 level. All CBF measurements were lower than those reported for normothermic, unanesthetized subjects of similar age. The response of the cerebral circulation to changes in CO2 tension was well-maintained during hypothermic cardiopulmonary bypass. CBF increased by an average of 1.07 ± 1.19 (SD) ml·100 g-1·min-1·mmHg-1 increased in temperature-uncorrected Pa(CO2) in group I, and by 1.05 ± 0.54 ml·100 g-1·min-1·mmHg-1 increase in group II.

Original languageEnglish (US)
Pages (from-to)576-581
Number of pages6
JournalAnesthesiology
Volume64
Issue number5
StatePublished - 1986
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Cardiopulmonary Bypass
Carbon Dioxide
Oxygenators
Gases
Temperature
Body Temperature
Hematocrit

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Prough, D., Stump, D. A., Roy, R. C., Gravlee, G. P., Williams, T., Mills, S. A., ... Howard, G. (1986). Response of cerebral blood flow to changes in carbon dioxide tension during hypothermic cardiopulmonary bypass. Anesthesiology, 64(5), 576-581.

Response of cerebral blood flow to changes in carbon dioxide tension during hypothermic cardiopulmonary bypass. / Prough, Donald; Stump, D. A.; Roy, R. C.; Gravlee, G. P.; Williams, T.; Mills, S. A.; Hinshelwood, L.; Howard, G.

In: Anesthesiology, Vol. 64, No. 5, 1986, p. 576-581.

Research output: Contribution to journalArticle

Prough, D, Stump, DA, Roy, RC, Gravlee, GP, Williams, T, Mills, SA, Hinshelwood, L & Howard, G 1986, 'Response of cerebral blood flow to changes in carbon dioxide tension during hypothermic cardiopulmonary bypass', Anesthesiology, vol. 64, no. 5, pp. 576-581.
Prough, Donald ; Stump, D. A. ; Roy, R. C. ; Gravlee, G. P. ; Williams, T. ; Mills, S. A. ; Hinshelwood, L. ; Howard, G. / Response of cerebral blood flow to changes in carbon dioxide tension during hypothermic cardiopulmonary bypass. In: Anesthesiology. 1986 ; Vol. 64, No. 5. pp. 576-581.
@article{955563acfcad4a02a9b6dde0d894ab82,
title = "Response of cerebral blood flow to changes in carbon dioxide tension during hypothermic cardiopulmonary bypass",
abstract = "Changes in cerebral blood flow (CBF) in response to changes in Pa(CO2) were measured by intraaortic injection of 133Xe in 12 patients during hypothermic (23-30° C) cardiopulmonary bypass. In each patient, CBF was determined at two randomly ordered levels of Pa(CO2) obtained by varying the rate of gas inflow into the pump oxygenator (Group I, n = 6) or by varying the percentage of CO2 added to the gas inflow (Group II, n = 6). Nasopharyngeal temperature, mean arterial pressure, pump-oxygenator flow, and hematocrit were maintained within a narrow range. In group I, a Pa(CO2) (uncorrected for body temperature) of 36 ± 4 mmHg (mean ± SD) was associated with a CBF of 13 ± 5 ml·100 g-1·min-1, while a Pa(CO2) of 42 ± 4 mmHg was associated with a CBF of 19 ± 10 ml·100 g-1·min-1. In group II, a Pa(CO2) of 47 ± 3 mmHg was associated with a CBF of 20 ± 8 ml·100 g-1·min-1, and a Pa(CO2) of 53 ± 3 mmHg was associated with a CBF of 26 ± 9 ml·100 g-1·min-1. Within group I, the difference in CBF was significant (P < 0.05); within group II, the difference in CBF was significant at the P < 0.002 level. All CBF measurements were lower than those reported for normothermic, unanesthetized subjects of similar age. The response of the cerebral circulation to changes in CO2 tension was well-maintained during hypothermic cardiopulmonary bypass. CBF increased by an average of 1.07 ± 1.19 (SD) ml·100 g-1·min-1·mmHg-1 increased in temperature-uncorrected Pa(CO2) in group I, and by 1.05 ± 0.54 ml·100 g-1·min-1·mmHg-1 increase in group II.",
author = "Donald Prough and Stump, {D. A.} and Roy, {R. C.} and Gravlee, {G. P.} and T. Williams and Mills, {S. A.} and L. Hinshelwood and G. Howard",
year = "1986",
language = "English (US)",
volume = "64",
pages = "576--581",
journal = "Anesthesiology",
issn = "0003-3022",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Response of cerebral blood flow to changes in carbon dioxide tension during hypothermic cardiopulmonary bypass

AU - Prough, Donald

AU - Stump, D. A.

AU - Roy, R. C.

AU - Gravlee, G. P.

AU - Williams, T.

AU - Mills, S. A.

AU - Hinshelwood, L.

AU - Howard, G.

PY - 1986

Y1 - 1986

N2 - Changes in cerebral blood flow (CBF) in response to changes in Pa(CO2) were measured by intraaortic injection of 133Xe in 12 patients during hypothermic (23-30° C) cardiopulmonary bypass. In each patient, CBF was determined at two randomly ordered levels of Pa(CO2) obtained by varying the rate of gas inflow into the pump oxygenator (Group I, n = 6) or by varying the percentage of CO2 added to the gas inflow (Group II, n = 6). Nasopharyngeal temperature, mean arterial pressure, pump-oxygenator flow, and hematocrit were maintained within a narrow range. In group I, a Pa(CO2) (uncorrected for body temperature) of 36 ± 4 mmHg (mean ± SD) was associated with a CBF of 13 ± 5 ml·100 g-1·min-1, while a Pa(CO2) of 42 ± 4 mmHg was associated with a CBF of 19 ± 10 ml·100 g-1·min-1. In group II, a Pa(CO2) of 47 ± 3 mmHg was associated with a CBF of 20 ± 8 ml·100 g-1·min-1, and a Pa(CO2) of 53 ± 3 mmHg was associated with a CBF of 26 ± 9 ml·100 g-1·min-1. Within group I, the difference in CBF was significant (P < 0.05); within group II, the difference in CBF was significant at the P < 0.002 level. All CBF measurements were lower than those reported for normothermic, unanesthetized subjects of similar age. The response of the cerebral circulation to changes in CO2 tension was well-maintained during hypothermic cardiopulmonary bypass. CBF increased by an average of 1.07 ± 1.19 (SD) ml·100 g-1·min-1·mmHg-1 increased in temperature-uncorrected Pa(CO2) in group I, and by 1.05 ± 0.54 ml·100 g-1·min-1·mmHg-1 increase in group II.

AB - Changes in cerebral blood flow (CBF) in response to changes in Pa(CO2) were measured by intraaortic injection of 133Xe in 12 patients during hypothermic (23-30° C) cardiopulmonary bypass. In each patient, CBF was determined at two randomly ordered levels of Pa(CO2) obtained by varying the rate of gas inflow into the pump oxygenator (Group I, n = 6) or by varying the percentage of CO2 added to the gas inflow (Group II, n = 6). Nasopharyngeal temperature, mean arterial pressure, pump-oxygenator flow, and hematocrit were maintained within a narrow range. In group I, a Pa(CO2) (uncorrected for body temperature) of 36 ± 4 mmHg (mean ± SD) was associated with a CBF of 13 ± 5 ml·100 g-1·min-1, while a Pa(CO2) of 42 ± 4 mmHg was associated with a CBF of 19 ± 10 ml·100 g-1·min-1. In group II, a Pa(CO2) of 47 ± 3 mmHg was associated with a CBF of 20 ± 8 ml·100 g-1·min-1, and a Pa(CO2) of 53 ± 3 mmHg was associated with a CBF of 26 ± 9 ml·100 g-1·min-1. Within group I, the difference in CBF was significant (P < 0.05); within group II, the difference in CBF was significant at the P < 0.002 level. All CBF measurements were lower than those reported for normothermic, unanesthetized subjects of similar age. The response of the cerebral circulation to changes in CO2 tension was well-maintained during hypothermic cardiopulmonary bypass. CBF increased by an average of 1.07 ± 1.19 (SD) ml·100 g-1·min-1·mmHg-1 increased in temperature-uncorrected Pa(CO2) in group I, and by 1.05 ± 0.54 ml·100 g-1·min-1·mmHg-1 increase in group II.

UR - http://www.scopus.com/inward/record.url?scp=0022501567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022501567&partnerID=8YFLogxK

M3 - Article

VL - 64

SP - 576

EP - 581

JO - Anesthesiology

JF - Anesthesiology

SN - 0003-3022

IS - 5

ER -