Response of human tumor cells of varying radiosensitivity and radiocurability to fractionated irradiation

William K. Dahlberg, Edouard I. Azzam, Yongjia Yu, John B. Little

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

The cytotoxic effects of radiation delivered in daily fractions of 2.0 Gy were examined in plateau phase cultures of human tumor cells of varying in vitro radiosensitivity, derived from tumors of varying radiocurability. Among the eight cell lines examined, three types of responses to fractionated irradiation were observed. In the group composed of tumor cell lines that were radioresistant in culture (D0 > 2Gy) and derived from known local radiation failures or from tumor histologies associated with radiation failure, a gradual linear reduction in surviving fraction versus total dose was observed. In a second group, composed of cell lines that were radiosensitive in culture (D0 ≃ 1 Gy) but derived from known radiation failures, the surviving fraction initially declined and began to plateau after 6 Gy (three fractions of 2 Gy). In the third group, composed of radiosensitive cell lines derived from tumors associated with high radiocurability, a rapid decline in surviving fraction versus total dose was observed. The in vitro response of human tumor cells to fractionated irradiation delivered at clinically relevant doses appears to be independent of in vitro X-ray sensitivity and p53 status but related to clinical radiocurability, suggesting a possible role in predicting tumor response to radiotherapy.

Original languageEnglish (US)
Pages (from-to)5365-5369
Number of pages5
JournalCancer Research
Volume59
Issue number20
StatePublished - Oct 15 1999
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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