Response of rats to repeated oral administration of endosulfan

T. S S Dikshith, R. B. Raizada, M. K. Srivastava, Bhupendra Kaphalia

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Male and female albino rats given different oral doses (0.75, 2.5, 5.0 and 0.25, 0.75, 1.5 mg/kg/D) of endosulfan respectively for a period of 30 days elicited signs of toxicity such as hyperexcitability, tremor, dyspnea and salivation for a brief period. At the tested dose levels, endosulfan produced no significant change in the organ body weight ratio, biochemical, histological, haematological and fertility indices. Residue analysis using GLC techniques of different organs revealed a higher level of α isomer in the fatty tissue of male and female rats, than in other organs. There was no significant accumulation of the α and β isomers of endosulfan in the vital organs inspite of repeated exposure which seems to be the reason for the absence of a severe toxicological response in the rats. The lower doses of endosulfan, however, showed none of the toxicological effects in male (.075 and 2.5 mg/kg/D) and female (0.25 and 0.75 mg/kg/D) rats.

Original languageEnglish (US)
Pages (from-to)295-304
Number of pages10
JournalIndustrial Health
Volume22
Issue number4
StatePublished - 1984
Externally publishedYes

Fingerprint

Endosulfan
endosulfan
Oral Administration
Rats
Isomers
Toxicology
Salivation
Organ Size
Tremor
Dyspnea
Fertility
Toxicity
Adipose Tissue
fertility
Body Weight
Tissue
toxicity
organ
dose
isomer

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Toxicology

Cite this

Dikshith, T. S. S., Raizada, R. B., Srivastava, M. K., & Kaphalia, B. (1984). Response of rats to repeated oral administration of endosulfan. Industrial Health, 22(4), 295-304.

Response of rats to repeated oral administration of endosulfan. / Dikshith, T. S S; Raizada, R. B.; Srivastava, M. K.; Kaphalia, Bhupendra.

In: Industrial Health, Vol. 22, No. 4, 1984, p. 295-304.

Research output: Contribution to journalArticle

Dikshith, TSS, Raizada, RB, Srivastava, MK & Kaphalia, B 1984, 'Response of rats to repeated oral administration of endosulfan', Industrial Health, vol. 22, no. 4, pp. 295-304.
Dikshith TSS, Raizada RB, Srivastava MK, Kaphalia B. Response of rats to repeated oral administration of endosulfan. Industrial Health. 1984;22(4):295-304.
Dikshith, T. S S ; Raizada, R. B. ; Srivastava, M. K. ; Kaphalia, Bhupendra. / Response of rats to repeated oral administration of endosulfan. In: Industrial Health. 1984 ; Vol. 22, No. 4. pp. 295-304.
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