TY - JOUR
T1 - Response to pneumococcal vaccine in the elderly
T2 - No enhancement by indomethacin
AU - Lafferty, William P.
AU - Selinger, Daniel S.
AU - Schiffman, Gerald
AU - Goodwin, James S.
PY - 1981
Y1 - 1981
N2 - We investigated whether indomethacin administration would augment the antibody response to pneumococcal vaccine in a group of healthy elderly individuals. There was no significant difference in mean increases in antibody levels to 12 pneumococcal polysaccharide types between the 20 subjects who received indomethacin 25 mg q.i.d. for five days after immunization and the control subjects not receiving indomethacin. In addition, there was no correlation within this group of 40 individuals between three measures of immune function (absolute lymphocyte count, delayed hypersensitivity testing, and response to phytohemagglutinin) and the antibody response to the pneumococcal vaccine.
AB - We investigated whether indomethacin administration would augment the antibody response to pneumococcal vaccine in a group of healthy elderly individuals. There was no significant difference in mean increases in antibody levels to 12 pneumococcal polysaccharide types between the 20 subjects who received indomethacin 25 mg q.i.d. for five days after immunization and the control subjects not receiving indomethacin. In addition, there was no correlation within this group of 40 individuals between three measures of immune function (absolute lymphocyte count, delayed hypersensitivity testing, and response to phytohemagglutinin) and the antibody response to the pneumococcal vaccine.
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U2 - 10.3109/08923978109026429
DO - 10.3109/08923978109026429
M3 - Article
C2 - 7338631
AN - SCOPUS:84907114865
SN - 0892-3973
VL - 3
SP - 241
EP - 250
JO - Immunopharmacology and Immunotoxicology
JF - Immunopharmacology and Immunotoxicology
IS - 2
ER -